What is the evidence that B3 vitamins benefit healthspan?

How do B3 vitamins support healthy aging?

Cardiovascular health supplements are still popular with seniors.

Hearty demand

Katrina Bogan-Brown, PhD, is founder and chief consultant at 

Average lifespan is defined as 73 years for men and 79 years for women. 

 a relatively newer term gaining popularity in the mainstream media, is not yet defined in precise quantitative terms. However, most agree it refers to the number of years that a person enjoys “good” health and is free of chronic disease and disability associated with aging.

Given this definition, extending healthspan is universally appealing, but is it possible, and how?

The first and most tested approach for extending healthspan is, of course, making healthy lifestyle choices. Getting enough physical exercise, eating a nutritious diet, and reducing stress are well-known foundational approaches to promoting health as chronological age increases. In addition to these, a growing body of data is revealing new, evidence-based approaches for extending healthspan.

Although research into human aging is still developing, with many important aspects still undiscovered, there is consensus that health and healthy aging is determined at the cellular level. To have a healthy brain, neuronal cells need to function optimally. To avoid diabetes, the pancreatic islet cells must make and secrete adequate levels of insulin and other hormones. A healthy heart requires healthy heart cells. Altered performance of just one type of cell within an organ can create conditions that alter function of the organ. Altered function of an organ has effects at the organismal level.

The cellular basis of aging is illustrated by the 

: genomic instability, telomere attrition, epigenetics, lost proteostasis, deregulated nutrient sensing, altered intercellular communication, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion—all subcellular phenomena.

While there are undoubtedly many inputs to these cellular functions, one molecule is central to them all. Nicotinamide adenine dinucleotide, or NAD+, is required for essential enzymatic reactions associated with each of the nine hallmarks of aging and is necessary for cells to function properly.

NAD+ is an essential co-enzyme required for cellular function across all orders of life. NAD+ is used as a co-enzyme in oxidation-reduction (redox) reactions, where it functions as an electron carrier and therefore exists in both oxidized (NAD+) and reduced forms (NADH). NAD+ also supports critical cellular functions by serving as a substrate of NAD+-consuming enzymes. These enzymes (sirtuins, CD38, and PARPs) are implicated in key cellular functions associated with aging. Their enzymatic activity breaks a bond in the NAD+ molecule, destroying it, thus making it essential that cells continually synthesize new NAD+ molecules to maintain adequate levels.

Cellular NAD+ levels decline with age—up to 65% between ages 30 to 70. Accordingly, NAD+ depletion is implicated in a variety of age-related diseases and age-related disease phenotypes, including neurodegeneration, diabetes, and progeroid diseases (such as Ataxia Telangiectasia and Werner Syndrome). Research has shown that restoring NAD+ through genetic and molecular means rescues aging and age-associated disease phenotypes in animal models.

In humans, NAD+ is made from precursor molecules, including tryptophan and the B3 family vitamins nicotinamide, nicotinic acid, and nicotinamide riboside (NR). These precursors enter cells and are chemically converted through biosynthetic pathways to NAD+ 

 Nicotinamide mononucleotide (NMN) is a nucleotide NAD+ precursor, which needs to be chemically converted to NR to enter most cells 

 although a specific transporter may allow direct transport of NMN into some intestinal cells in mice. Studies are needed to determine the physiological relevance of this transporter to disease, the kinetics of NMN uptake, and tissue-specific expression in mammals.

While each of the NAD+ precursors can be found in a healthy varied diet, higher levels may be needed to support cellular health and combat NAD+ decline associated with aging. Among NAD+ precursors, NR and its reduced form NRH are the most orally bioavailable. To date, 

 demonstrating the safety and/or activity of NR in humans, and a total of 84 

 are currently listed in the U.S. repository for clinical trials maintained by the National Institutes of Health. 

 are also ongoing, and several have been 

, although the FDA recently withdrew the new dietary ingredient (NDI) status of NMN and 

 saying it could not be sold as a supplement.

Clinical trials completed to date showcasing NR as a potential therapeutic strategy for age-related diseases include:

a phase 1 trial in participants with Parkinson’s disease, which showed that NR increased cerebral NAD+ levels, altered brain metabolism, and elicited clinical improvement;

a trial in participants with mild-to-moderate Alzheimer’s disease that demonstrated an increase in neuronal NAD+ levels and a decrease in biomarkers related to neurodegenerative pathology;

a trial in Stage C heart failure patients with reduced ejection fraction that showed increases in whole blood NAD+ levels and white blood cell mitochondrial respiration and a decrease in expression of inflammatory cytokines;

a trial in patients with nonalcoholic fatty liver disease, in which NR treatment reduced liver fat;

a study in patients with systemic lupus erythematosus, which showed that NR, combined with other metabolic activator agents, reduced inflammation in monocytes; and

the first ever trial of oral NR conducted in children with Ataxia Telangiectasia, which showed improved Ataxia Scores and immunoglobulin levels in participants.

Notably, the Parkinson’s disease trial results were sufficient to justify 

, which is being funded by the Norwegian government to further examine the ability of NR to improve scores on the Movement Disorder Society’s Unified Parkinson’s Disease Rating Scale (UPDRS).

other completed and ongoing clinical trials

 warrant the attention of healthcare providers and suggest that NR represents a safe and effective supplement that may help patients maximize health in their later years.

López-Otín, C.; Blasco, M.A.; Partridge, L.; Serrano, M.; Kroemer, G. The Hallmarks of Aging. 

Articles

Jennifer Grebow is the editor-in-chief of 

, an award-winning media-content provider in the dietary supplement and natural products market. 

, an MJH Life Sciences brand, provides insights and industry updates critical to manufacturers of dietary supplements, healthy foods, and nutritious beverages. 

 keeps industry abreast of current market trends, research updates, news, and regulatory developments. 

goes beyond the 24-hour news cycle and provides in-depth analysis to help industry players navigate the challenges and changes in the near- and long-term. 

, the largest privately held, independent, full-service medical media company in North America, dedicated to delivering trusted health care news across multiple channels.

Many of today’s trending diets—including plant-based, Mediterranean, and high-fiber diets—are rich in fermentable carbohydrates that the human gut may have trouble digesting. These fibers, or FODMAPs—which stands for “fermentable oligo-, di-, monosaccharides and polyols”—can ferment in the human gut, causing gas and resulting in abdominal bloating, cramping, and flatulence. Ingredient supplier Bio-Cat (Troy, VA) has announced publication of a new preclinical study that found that supplementation with an enzyme called inulinase could help address negative gut symptoms associated with consuming one kind of FODMAP in particular: fructans.

“While FODMAPs include a broad range of carbohydrates, it is the fructans and galactans [or galactooligosaccharides (GOS)] that are particularly aggravating with respect to food intolerance,” the study’s researchers, who are employees of Bio-Cat, write. They go on to explain that dietary strategies aiming to minimize the impact of FODMAPs have so far included eating low-FODMAP diets and/or processing ingredients and foods to lower their FODMAP content. They point out, however, that such approaches can involve more expensive foods as well as limited access to low-FODMAP foods in social settings.

The third option, the researchers state, would be using enzyme supplements to help the body process the FODMAPs in foods in order to alleviate negative digestive effects. “Supplemental enzymes have the potential to reduce FODMAP burden through enhanced gastric and intestinal digestion without restricting healthy, fiber-rich food choices,” they state.

In their study, which Bio-Cat funded, the researchers focused on one category of FODMAPs: fructans. (Other FODMAPs include lactose, found in dairy products, and galactans, found in legumes.) Fructans like inulin are found in certain fruits and vegetables. According to Bio-Cat, some research has shown that consuming fructans like inulin can lead to gut inflammation.

The researchers looked at whether supplementing with the enzyme inulinase may help break down fructans that the human gut enzymes would otherwise not naturally hydrolyze. “The R&D team at Bio-Cat, an industry leader in digestive health specializing in enzymes and probiotics, hypothesized that microbial inulinase supplementation can promote dietary fructan digestion in the stomach into fructose that can be absorbed by the upper intestine, rather than fermenting in the lower intestine, leading to digestive symptoms,” the company’s press release states.

In the preclinical study, the researches applied inulinase to high-FODMAP samples of either inulin, garlic, or foods containing inulin or garlic. They used a model of static simulation of digestion in the gastrointestinal system that was adapted from the INFOGEST model. Based on what they saw, they determined that inulinase supplementation may help “break down dietary fiber and reduce dietary FODMAP exposure.” They recommended advancing to safety, tolerability, and efficacy trials in humans.

Bio-Cat says it has now initiated a clinical trial (ClinicalTrials.gov Identifier NCT05744700) “to determine the safety and tolerability of high-dose microbial inulinase supplementation.”

In the press release, Sean Garvey, PhD, one of the study researchers and director of enzyme research and development at Bio-Cat, stated, “Currently, there are consumer products available on the market promoting the digestion of lactose and galactans; however, there remains an opportunity for improving digestion of fructans found in vegetables like onion and garlic.”

Guice, J.L.; Hollins, M.D.; Farmar, J.G.; Tinker, K.M.; Garvey, S.M. Microbial Inulinase Promotes Fructan Hydrolysis Under Simulated Gastric Conditions. 

Bio-Cat announced publication of a new preclinical study that found that supplementation with an enzyme called inulinase can help address negative gut symptoms associated with consuming one kind of FODMAP in particular: fructans.

Inulinase enzyme supplementation may counter digestive distress associated with consuming fructans from plant-based and FODMAP diets, study finds

Nordic Naturals announced that its Nordic Flora Probiotics line is now being sold at Sprouts. The high-potency Nordic Flora Probiotics products target concerns like immune, digestive, and women’s health. They are available in the refrigerated section in more than 375 Sprouts Farmers Markets nationwide.

The Nordic Flora Probiotic Immune Health supplement blends 15 probiotic strains, providing 60 billion cultures per capsule, to support a healthy immune response, enhance intestinal barrier function, and promote immune cell responsiveness, the company says.

The Nordic Flora Probiotic Maximum Care supplement supports both immune and digestive health. The product is high in colony-forming units (CFU), blending 11 probiotic strains and providing 90 billion cultures per capsule. “The Maximum Care probiotic positively affects the immune system both directly and indirectly by alleviating intestinal bloating while promoting gastrointestinal comfort and regularity,” the company’s press release states.

Finally, the Nordic Flora Probiotic Women’s Balance supplement is designed to help maintain a healthy vaginal microbiome while supporting the microbes naturally present in the gut. It is a blend of 12 probiotic strains, including the highly researched 

NCFM probiotic strain, and contains 60 billion CFU per capsule.

“Factors like stress, aging, diet, environmental toxins, medications, and a sedentary lifestyle can lead to less abundant bacteria and diversity,” the company states. “Maintaining a healthy balance of these bacteria is important for immune and digestive function, skin health, cognition, mood, and much more, which is why probiotic supplementation is so essential.”

Sprouts is also now featuring the line’s Nordic Flora Prebiotic Powder in its stores’ refrigerated sections.

The Nordic Flora Probiotics products target concerns like immune, digestive, and women’s health.

Nordic Naturals’ high-potency, multi-benefit Nordic Flora Probiotics line debuts in Sprouts stores

 extraction facility in Bunnell, FL. Photo courtesy of Vidya Herbs.

India-headquartered herbal extracts supplier Vidya Herbs is investing in the U.S. by opening a CO

 extraction facility in Bunnell, FL. The Florida facility will serve as the company’s main hub for U.S. operations, the firm says.

The company calls the new extraction facility state-of-the-art. “The new Vidya Herbs USA headquarters encompasses a spacious and modern facility equipped with cutting-edge infrastructure,” the company’s press release states. “The facility’s design complies with the highest industry standards. It employs a state-of-the-art supercritical CO

 extraction process, which preserves the potency and purity of phytochemicals in an environmentally friendly manner.”

The Bunnell location is strategically located in a thriving agricultural community and has good access to transportation networks, enabling efficient distribution and logistical operations across the U.S., the firm adds.

“This expansion reflects our commitment to the American market,” said Shyam Prasad, president of Vidya Herbs USA, in a press release. “The opening of Vidya Herbs’ Florida headquarters will create numerous employment opportunities in the region, contributing to economic growth and further establishing Bunnell as a hub for the herbal extracts industry.”

The Florida facility will serve as the company’s main hub for U.S. operations.

India-based herbal extracts supplier Vidya Herbs invests in U.S. with new extraction plant in Florida

There are images of artichokes on the walls of temples and tombs of pharaohs, demonstrating their significance to ancient Egyptians.

http://herbalgram.org/resources/herbalgram/issues/130/table-of-contents/hg130-herbprofile-artichoke/

Fun fact! There are images of artichokes on the walls of temples and tombs of pharaohs, demonstrating their significance to ancient Egyptians.

Artichoke history

While there is a lot of discussion about gummies as a fast-growing and popular dosage format for dietary supplements, traditional dosage formats such as capsules are not going anywhere. They allow for highly complex and fills that make it possible for dietary ingredients to impart their benefits. Softgel capsules, in particular, are a popular dosage format for dietary supplements with a number of advantages for formulators.

“In softgel [capsules], the fill materials are really protected from oxygen,” explained Michael Baumann, global strategic marketing manager, dietary supplements, at IFF’s Pharma Solutions (New York City). This protects ingredients that are less stable and more susceptible to oxidation. Fish oils, for example, are a very popular fill for softgel capsules because they are prone to oxidation when exposed to air. Aesthetics is also a factor when using softgel capsules.

“[Softgel capsules are a] very elegant dosage form that you can achieve different aesthetics depending on your brand strategy,” said Benjamin Roscoe, application and innovation manager for IFF’s Pharma Solutions. “It's adaptable to different colors, you can take on different sizes and shapes. You can make them colorless and if you have a nice colored fill they can come through as looking almost like a gem or a crystal.”

While a tried-and-true method of delivering dietary ingredients, the industry is constantly improving itself and solving new problems. IFF, for example, launched during Vitafoods Europe 2023, a carrageenan-free softgel technology called Verdigel SC which is a ready-to-use pectin-based premix that only requires the addition of water and a plasticizer to produce high-performance softgels. This is particularly significant as IFF specializes in vegan softgel capsule technology, with carrageenan being a component of its successful SeaGel softgel technology.

“The utility of carrageenan is that its chemistry as a primary film former conveniently lends itself to the vegan softgel dosage form,” explained Roscoe. “Over the years, as we evaluated the other chemistries on the market, we found that there was a need for a carrageenan chemistry that worked very well. And that is why we developed SeaGel. It's a tailored chemistry that was made for the soft capsule application and through that it provides fantastic film forming properties. That lend itself to a wide variety of different soft capsule possibilities: very large capsules, those encapsulating very difficult, complex fill materials, even those with high viscosity.”

“We kept hearing from our customers that they're looking for additional tools in their toolbox, additional options to formulate vegan softgels. And what we kept hearing is that they're looking for an additional option that is carrageenan free,” said Baumann. Having the ability to formulate “clean label” products is a big motivation for manufacturers as consumers actively avoid ingredients such as carrageenan.

On the other end of the spectrum, Gelita (Eberbach, Germany), which specializes in gelatin-based formulations also showcased new softgel capsule technology with its Gelita EC, an enteric release softgel capsule. According to Gelita, this new technology is easier and more cost effective than other enteric release options. According to Oliver Wolf, head of B2B marketing, global marketing and communication, for Gelita, enteric release capsules have to go through a two-step process in which the capsules are filled with the active ingredient, then have to go through a separate process to be coated. Sometimes, the coating process can take place at a completely different facility, Wolf explained. Gelita EC, in contrast, is already enteric. This means the capsule is able travel through the stomach, survive the acidic environment and be release in the intestine.

Enteric release can be beneficial for a number of fills, including fish oils in order to avoid the fishy burps often associated with those products, as well as probiotics. Live bacteria needs to survive the gut in order to populate the small intestine. Enteric release capsules can therefore greatly improve the effectiveness of ingredients like probiotics, which are immensely popular and only continue to grow as our understanding of the gut microbiome becomes more sophisticated.

Softgels are still a desirable dosage format, and innovation continues to deliver high quality and effective dietary supplements. Highlights include clean-label carrageenan free vegan softgels and improved enteric release technology.

Softgel sophistication: Vitafoods Europe 2023 report

There is a growing openness about menopause and the needs related to that stage of women’s lives, but women also have needs across multiple life stages that the dietary supplement industry can help with. While a number of products already exist that target the specific needs of women, the category will only become more sophisticated as the body of scientific literature grows and manufacturers invest more in new product development to meet demand.

An important place to start is motherhood, because there has been a lot of innovation when it comes to infant nutrition, with supplements expecting mothers can take to support the healthy development of their fetus as well as fortify the nutritional value of their breast milk when nursing their babies during infancy. A probiotic strain called LC40 (

 CECT5716) from Kerry Group (Tralee, Ireland), can offer support to both the mother and infant. Specifically, LC40, a probiotic strain isolated from human breast milk of healthy mothers, has been shown to reduce the incidence of mastitis, which is the inflammation of the breast tissue.

“If you reduce [mastitis], then parents can manage to breastfeed longer because mastitis, of course, is very painful and mothers stop breastfeeding,” explained Alexandra Boelrijk, global senior director of RDA, ProActive Health for Kerry Group. “The same strain is actually also used in infant formula, for immune and digestive benefits. You see probiotics in infant formula coming up more and more because in mother's milk there's also probiotics, so [manufacturers are] trying to be as close to human milk as possible.”

“All [our] research…about probiotics in women during breastfeeding is related with microbiota in [the] mammary glands. But it's not just about the women, it's also about the benefits for the infants,” added Monica Maria Olivares, RDA director for women and infant health, with Kerry. “We have observed that women consuming a probiotic strain during breastfeeding period obtain benefits for the infant, so everything is connected.”

So, strains like LC40 not only improve the quality of life of mothers by reducing discomfort, but also extend breastfeeding so that the infants can receive the benefits of mother’s milk associated with the strain. At the same time, if a mother chose to bottle feed, infant formula manufacturers can leverage these kinds of strains to make their products as similar to mother’s milk as possible.

Other strains such as IFF Health’s (Londerzeel, Belgium) 

Lactobacillus acidophilus La-14 and Lactobacillus rhamnosus HN001

 have been shown to impart immune health benefits to infants when consumed by the mother during pregnancy, as well as a lower prevalence of eczema. Mothers benefited by having a reduced prevalence of gestational diabetes, as well as supporting a healthy vaginal microbiome.

Of course, before women can become mothers, they must first get pregnant. Fertility is something many women might struggle with, which creates opportunity for products touting fertility benefits, but it’s also controversial for this reason as dietary supplement cannot and should not make irresponsible treatment claims. That said, innovations in herbal formulas may help women in specific situations. For example, Caronositol from Kerry, which is a combination of Myo-inositol from the phytin of corn, and D-chiroinositol from carob fruit that may support hormonal balance in women of reproductive age. Hormonal problems such as polycystic ovary syndrome (PCOS) may affect women’s ability to conceive. One 

 found that women with PCOS undergoing Intracytoplasmic sperm injection saw a significantly higher rate of pregnancy and live birth after being given a higher ratio of myo-inositol and d-chiroinositol.

Credibility is crucial in this area because fertility is a such a sensitive and personal problem for so many women. Good quality clinical data provides this credibility while honest marketing instills trust. “It's important to explain the mechanisms [of action] to handle [consumer] expectations,” said Olivares. “If your problems are not related, in the case Caronositol, with the hormonal disbalance, this [ingredient] is not going to help.”

When it comes to urinary tract health, cranberry has always been the star ingredient. However, these ingredients are becoming increasingly more sophisticated as the body of research about proanthocyanidins (PACs) grows. For example, Symrise (Holzminden, Germany) offers a standardized cranberry extract called Urophenol that has been found in

 to reduce the incidence of symptomatic urinary tract infections by 43% in women who experienced fewer than five urinary tract infection in the year prior to enrollment. According to Nathalie Richer, global health business leader, naturals food and beverage, taste, nutrition, and health at Symrise, the company investigated the ingredient’s mode of action and discovered something surprising.

“We realized that everything was happening in the gut and not in the urinary tract,” said Richer. “So, it was very closely linked to the microbiota. The prevention of the development of the bacteria was realized in the gut by inhibiting the colonization of the bacteria and also supported the production of some metabolites.”

After observing these effects, Symrise launched a 

 in 2018 in partnership with the Laval University (Québec) and co-funded by the National Science and Engineering Research Council (NSERC). The result is the launch of Prebiocran, a cranberry extract standardized to 30% total polyphenols. A number of interesting studies informed the development of this product. For example, an unpublished human clinical trial of 39 health subjects found that daily consumption of 480 mg of Prebiocran influenced the basal human gut microbiota beta-diversity after four days, particularly inducing a blood of 

As knowledge of the prebiotic effects of cranberry grows, probiotics can be a great complement to cranberry products. For example, AB-Biotics (Barcelona, Spain) offers AB-Cyscare, which is the combination of 

 KABP 063 strains that can be used alone or in combination with cranberry to support urinary tract health. 

 shows evidence that the strains can significantly decrease the growth of pathogens associated with urinary tract infections.

Menopause is experiencing a big push because there has been such a taboo about this stage of women’s lives that there are often misconceptions and poor understanding about menopause. Women are becoming more vocal about their experiences with menopause in order to improve their quality of life, and this presents an opportunity for dietary supplement manufacturers.

According to Gen M, an organization based in the UK whose mission to help make menopause a positive experience, an estimated 1 billion globally will experience menopause by 2025, and because this natural transition in life can have 48 different symptoms and last up to 12 years for 10% of women, the experience can be confusing and difficult to navigate. A 

 published by Gen M found that 94% of perimenopausal and menopausal women believed they “would benefit from brands being more inclusive and catering better to menopausal women.”

Read more about opportunities in menopause support 

A great deal of dietary supplement marketed toward women are simply that, marketed toward women. For example, beauty products for the support of hair, skin, or nails are often marketed toward women but can be used just the same by men. What women want are products that help them deal with specific aspects of feminine health. The pool of products that fit this description is growing, but continue to keep an eye on clinically validated ingredients that help women across various life stages and the many need states that can manifest for women when their bodies change with age.

The future of women's health is tailored solutions that assist women throughout multiple life stages. 

Meet the demand for more tailored solutions in women’s health: Vitafoods Europe 2023 report

Mike Straus is a freelance writer living in Kelowna, Canada. He has written for publications including 

Canadian Chiropractor Magazine, Massage Therapy Canada, 

The heart health supplements market is still growing robustly, particularly among aging consumers. While previous market trends showed consumers adopting supplements only once health problems arose, emerging research indicates aging consumers are increasingly proactive and are taking a preventative approach to heart health.

As consumers seek to live longer and stay healthier into old age, cardiac health has come into sharp focus for seniors and older adults. Here are some of the ways heart health supplements are evolving to meet this demand.

Brands Emphasize Science in Marketing Campaigns

Consumers are increasingly focusing on extending their longevity and living healthier in old age. In doing so, they’re looking for solutions with a critical eye.

Christopher Shade, PhD, founder and CEO of wellness brand Quicksilver Scientific, says aging consumers are increasingly sophisticated in their understanding of heart health strategies, and they’re looking for high-quality, personalized solutions.

“We’re seeing more consumers who are focused on longevity,” Shade says. “They’re asking questions about aging well. From a brand perspective, it’s important to bring research and education to these consumers. They’re often highly educated and knowledgeable about what they want.”

While consumers typically took a reactive approach in the past, Shade says aging consumers are now more proactive. These consumers are no longer waiting for health problems to arise; instead, they’re looking to prevent health problems, and they’re eager to adopt strategies tailored to their individual needs. That’s why Shade says it’s important for brands to bring research and education to these consumers, and to describe the science behind products.

Formulations Target Comprehensive Heart Health

Emerging heart health supplements are taking a holistic approach to heart health. Irfan Qureshi, ND, vice president of product development, research, and quality assurance at wellness company Healthy Directions, says heart health supplements are now evolving to provide more comprehensive coverage.

There is an increasing recognition that heart health is about more than just cholesterol support or the functioning of the heart itself, Qureshi says. “Products now address additional concerns like mitochondrial function, inflammatory markers, endothelial function, circulation and blood vessel health, and the heart-brain connection,” Qureshi says. “Newer ingredients offer multiple benefits across the category. [This includes] ingredients that target inflammation.”

While established heart health ingredients like coenzyme Q10 and magnesium are still playing a role in this market, Qureshi says herbal and botanical ingredients rich in polyphenols are now entering the heart health space in addition to ingredients that target inflammation. These include resveratrol, citrus bergamot, and curcumin from turmeric.

“Probiotics have also entered the space, with research showing various strains promoting heart health, including a reduction in inflammation as well as support for healthy cholesterol levels,” Qureshi explains. “There is now recognition among consumers that lifestyle factors alone may not be enough to maintain a healthy heart in old age; supplements should be seen as a key [component]…for improvements in heart health.”

The healthy-aging market offers a unique opportunity for heart health supplements. Shade points out that aging touches every part of the body, including the digestive system. That means as consumers age, their appetites drop and their digestive systems slow. As a result, aging consumers may struggle to meet their nutritional needs through diet alone.

“Conventional supplements taken by mouth may also lose effectiveness, with only a small fraction of the compounds metabolized,” Shade explains. “Fortunately, we have the technology to deliver supplements in highly bioavailable formats. Quicksilver Scientific’s liposomal delivery system allows nutraceuticals to pass between cells and enter the bloodstream after ingestion, reaching the harsh digestive tract that may not be optimally functioning in many aging people.”

The heart health supplements market is expanding as aging consumers begin to prioritize preventive solutions. Consumers are no longer approaching heart health in a reactive manner; instead, aging adults are proactively seeking out ways to maintain their heart health well into old age before problems arise.

Brands are responding to this demand with a renewed focus on science-driven educational marketing that highlights supplements’ unique role and opportunity in promoting heart health. Ingredients like botanicals, minerals, and curcumin are all finding room to play in this arena. As the population gets grayer, expect more opportunities for proven ingredients that can provide comprehensive cardiovascular support.

What are the emerging trends in heart health supplements?

Hearty demand: Cardiovascular health supplements are still popular with seniors

Shivani Bisht is an associate consultant, food and nutrition, for 

. ChemBizR is a boutique business research and consulting partner of chemical companies globally, involved in addressing companies’ critical business challenges and strategic growth initiatives to help them transform their enterprise for sustainable growth in a highly competitive and rapidly evolving environment. For more information, e-mail 

Athletes are well aware of the importance of nutrition in optimizing and improving overall performance. Sports nutrition is a multidisciplinary field that prioritizes the principles and applications of a healthy diet. The American College of Sports Medicine (ACSM) describes how optimal nutrition enhances physical activity, athletic performance, and even recovery rates post-workout.

Across Europe, concerns about health and growing obesity rates have spurred an increase in health clubs and fitness centers. In addition, the market for sports nutrition products reached nearly 4 billion euros in 2020. The European sports nutrition market expects a steady, promising growth rate of over 5% until 2025.

In Europe, the main consumers of sports nutrition products have traditionally been athletes and sportspersons, but the demand is now coming from a broader cluster of customers. Both sports professionals and beginners are looking for nutritional products that are ideal for pre- and post-workout recovery as well as for providing a push to their training routines. In addition, along with improved physical performance and fitness levels, there is a growing emphasis on improving mental health and preventing chronic disorders. With changing demands and consumer personas, new sports nutrition product launches have accelerated.

Among other macronutrients, fat is the third most important element in sports nutrition and is included in products in a variety of forms, such as base oils, medium-chain triglycerides (MCTs), and lipids. Currently, base oils account for the majority of the European market, with MCTs and lipids together accounting for less than 20% of the market.

In this article, we explore the market dynamics of each of these oils in Europe’s sports nutrition market in terms of cost, performance, functionality, accessibility, and dosage.

Types of Product Formats in Sports Nutrition

The sports nutrition market is currently divided into four major segments:

 A powder is a mixture of vital nutrients that can be consumed before or after exercise by combining it with milk or water. Powders can deliver large doses of ingredients and allow consumers some degree of customization. They have occupied the largest segment of the sports nutrition market with a share of more than 40%.

 This class includes beverages that claim to help athletes replenish their lost glucose, fluids, and electrolytes (sodium, potassium, magnesium, and calcium) during or after training or competition. The segment shows promising growth in the future with the introduction of new flavor and ingredient-based drinks to meet evolving consumer demands.

 Nutrition bars are one of the most practical and well-balanced foods in terms of macro- and micronutrients, and they are primarily used by athletes or exercise enthusiasts for muscle growth.

 Ready-to-drink (RTD) forms of protein and other weight-loss supplement powders are typically sold in flavored milkshake varieties. The market’s growth is anticipated to be significantly higher than that of the overall sports nutrition market in Europe and will be fueled by products offering ease of consumption and a wide range of flavors.

The Potential of Base Oils in Nutritional Bars

Base oils provide energy to the body, aid in the absorption of fat-soluble vitamins, and fulfill the body’s requirement for essential fatty acids for healthy growth, development, and maintenance. Over 90% of the market for base oils is shared by nutritional bars.

One of the key factors behind sunflower oil’s growing popularity in sports nutrition bars and powders is its high-oleic oil content, which aids in promoting healthy fats in the body. Palm oil is one of the most commonly used base oils because it is less expensive and more widely available than other base oils.

Given that customers are becoming more aware of the health benefits of coconut oil, there has been more emphasis on including it in sports nutrition products in recent years. Coconut oil is an appropriate substitute for palm oil because it can provide the required total fat content while containing a lower percentage of unhealthy saturated and trans fats and has a potential growth rate of nearly 6% by 2025.

Canola oil is typically used when combined with other base oils like palm or sunflower oil because it is unable to offer the necessary fat profile on its own.

Scientific research has linked medium-chain triglycerides (MCTs) with improved body fat metabolism and considerable improvements in metabolic rate. It is a type of fat that is more easily absorbed by the digestive system than conventional lipids. MCT oil has the potential to help with weight loss and can be utilized as an instant energy source. Additionally, it can prevent bacterial development and help in the treatment of several neurological diseases. With a market share of more than 90%, medium-chain triglycerides are quickly becoming a very popular component in sports nutritional powders, especially those aimed toward weight loss and the ketogenic diet.

For better product stability, fats are also added in the form of emulsifiers, both synthetic (SSL or monoglycerides) and natural (lecithin). Soy lecithin is a popular natural emulsifier for both bars and powders because it can provide the necessary emulsification without significantly increasing the overall fat content of the finished product. It usage is also expected to grow at the fastest rate among the categories, by nearly 4% by 2025. Linoleic acid is commonly used in supplement powders for low-sugar diets because it can help control the body’s insulin levels.

Given the rising awareness of health concerns and the increasing availability of product choices, Europe presents amazing growth opportunities in the sports nutrition market.

To replace sugar while still maintaining taste, low-sugar products are beginning to appear on the market, such as the Baouw Organic Beetroot, Almond, and Espelette Pepper Nutritional Bar and Grenade Go Nuts Peri-Peri High-Protein Low-Sugar Bar. The flavor of these products may range from salty to even spicy (pepper, peri-peri).

The most prominent product claim by recent performance nutrition product launches in Europe is for high/added protein. While whey protein continues to dominate the market for sports nutrition products, interest in plant-based proteins is rising because of environmental concerns. Some interesting product lines on the market have come from Emco and BioTechUSA. Emco’s nut and protein bars contain vegetable protein sourced from soy, while BioTechUSA protein bars contain protein sourced from rice and peas to entirely complement the protein intake of the sportsperson.

The COVID-19 wave heightened interest in bioactive compounds associated with traditional medicine, prompting people to seek out more holistic methods of staying healthy. As a result, certain sports nutrition firms have started including these bioactive ingredients in their products, particularly those derived from natural sources, like ginseng, pine bark, ginger, vitamin C, etc. The Olimp Sport Nutrition powder brand contains extracts from both Korean and Siberian ginseng to improve blood circulation and regeneration in the body.

The American Nutrition Association defines 

 as a field that includes dietary recommendations for disease prevention, management, and treatment for individuals with varying health concerns and issues. This idea has a lot of potential, and it’s growing significantly in Europe as people want to customize and choose what’s best for them based on their unique physical, mental, and lifestyle requirements. The result is products like the flavored energy bars recently launched by brands such as Milbona, Yamo, Corny Haferkraft Zero, and Monoprix Bio.

The demand for sports nutrition products in Europe has skyrocketed, owing to a large number of consumers, particularly the Millennial and Gen Z population, who have a defined focus and interest in health and fitness. The region also exports its products to Middle Eastern and African countries, with a large number of production facilities in countries such as Germany, the Czech Republic, and Poland, among others.

With the continuous shift towards convenience foods, there will be growing demand for travel-friendly products like energy bars that can provide all or the maximum sports nutritional components within one product. One challenge to keep in mind is that because fat is highly correlated with weight gain and cardiovascular diseases, consumer education will be needed to spread information about the positive aspects of fats such as base oils, MCTs, and emulsifiers in sports nutrition products in Europe.

A snapshot of Europe’s sports nutrition market—and the use of oils and fats, specifically—by ChemBizR.

Sports performance: Unleashing the nutritional potential of oils and fats in Europe

 (Buffalo, NY). Hailing from a background in finance, Scott is well-versed in the benefits of hemp and is passionate about providing people with a natural alternative to the pharmaceuticals.

In 2018, cannabidiol (CBD) became suddenly legalized under 

. However, regulators were caught off-guard by the 2018 ruling, and clarification regarding production standards largely never eventuated.

In the forthcoming five-year update to the cornerstone agricultural policy, CBD producers and consumers deserve oversight and more information regarding issues like CBD’s dietary supplements usage, purity and potency thresholds, and the issue of delta-8 THC. Let’s explore.

The Question of CBD and Dietary Supplements

It’s important to keep in mind that food and drinks containing CBD have never actually been approved by FDA. Instead, the 2018 Farm Bill meant that CBD derived from hemp containing less than 0.3% tetrahydrocannabinol (THC) by dry weight was no longer considered a controlled substance. However, this does not mean the resulting products were FDA-approved.

While you may have seen products for sale—from candies to drinks at gas stations and wellness stores—they exist in legal limbo. And this uncertainty is a headache for much of the industry. In the year after the 2018 Farm Bill, 

 that 90% of CBD businesses operated in a legal gray area.

But there is regulatory movement on the horizon. As 

 FDA has concluded that CBD needs its own separate regulatory pathway separate for dietary supplements and food. The agency states that “a new regulatory pathway for CBD is needed that balances individuals’ desire for access to CBD products with the regulatory oversight needed to manage risks.”

It remains to be seen what happens from here, but some are already disappointed. The agency is signaling that it will not allow CBD to be marketed as a dietary supplement. This is an unfortunate development, as early studies show CBD’s potential benefits for 

. However, on the other hand, the agency rightfully highlights the importance of risk management regarding production. Case in point: preventing contaminants and assuring potency limits.

The CBD industry’s lack of regulation and enforcement has resulted in producers having free rein over the purity and potency of their products. As a result, many products are untested for these parameters, carry incorrect label information, and exceed legal contaminant limits.

This is not just a case of a few bad apples. Nearly half of the products tested in 

 delivered the wrong amount of CBD as advertised on the label. Moreover, 

, “CBD” samples turned out to be high-THC cannabis products, which could have alarming and even dangerous effects on unsuspecting consumers. More than 40% of the samples exceeded legal limits for pesticides and heavy metal contaminants.

These findings emphasize the urgent need for regulation—especially when users are accessing these products for their health. Let’s hope that the upcoming Farm Bill holds producers accountable for what they create. At a minimum, regulators should set purity and potency thresholds and include funding for enforcement. Further, on the industry side, producers should pressure each other to publish third-party lab results and confirm that their products do what they say they do. This will help to allay fears of product contamination; after all, 

Finally, there’s the question mark lingering over delta-8 THC. While the psychoactive compound is technically legal under federal law, it is banned in 20 states due to concerns that its legalization is a loophole.

Delta-8 THC is not found naturally in significant amounts. So, it is instead 

. A survey of 500 delta-8 users found that the majority experienced relaxation, pain relief, and euphoria when using these products.

 the legality of delta-8 products under the 2018 Farm Bill. However, the court acknowledged that if an unintended loophole was created, “then it is for Congress to fix its mistake.” I agree. The 2023 Farm Bill should clarify its ruling and make a clear judgement on delta-8 THC.

Further, the bill should sort out the legality of the broader range of synthetic psychoactive cannabinoids. Beyond delta-8 THC, legal hemp is also used to create delta-10 THC, THC-O, THC-A, THC-X, and a slew of others. Again, regulators need to give better assurances to consumers and producers of these compounds.

Safeguard Users and Improve Outcomes with the 2023 Farm Bill

The 2018 Farm Bill was by no means perfect. But, it did open the door to an entire industry and a new way of wellness. It’s now up to legislators to acknowledge the issues, step up, and deliver certainty in the 2023 Farm Bill.

As a producer in this industry, I hope FDA reconsiders its position regarding CBD as a dietary supplement. There are countless cases of this compound—when created safely by professionals—offering holistic health benefits. Moreover, there is an argument to be made that the safety and quality of products can be adequately addressed with regulation rather than an entirely separate approvals pathway.

Whatever happens, let’s look forward to ongoing and considered discussion between the industry and the regulators. Only then can we help evolve this landmark legislation into something which best safeguards users and improves health outcomes.

Here’s why the 2023 Farm Bill must clarify CBD’s legal status for the food, beverage, and supplement industries, writes Scott Mazza of Vitality CBD.

Featured Content

How do B3 vitamins support healthy aging?

Hearty demand