Juvecol, a proprietary proteoglycan sourced from salmon, supports skin moisturization in a recent study

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A recent study published in Japanese Pharmacology & Therapeutics¹ found that supplementation with salmon nasal cartilage proteoglycan (Juvecol from Maypro; Purchase, NY) supported skin moisture in subjects dealing with dry skin from office air conditioning. In the randomized, double-blind, placebo-controlled study, 56 healthy subjects between the ages of 20 and 58 years were given a supplement containing 5 mg of the salmon proteoglycan, or placebo every day for six weeks.

Results showed that supplementation with the salmon proteoglycan exerted skin moisturizing effects by improving skin hydration and reducing transepidermal water loss (TEWL). Measuring skin moisture content in subjects’ cheeks, necks, and legs, researchers found that six weeks of supplementation significantly improved skin moisture in the cheeks of subjects in their 40s, and suppressed TEWL in females legs after three weeks of supplementation. In subjects aged 40 years and older with TEWL ≤22 g/h/m2, proteoglycan supplementation significantly increased skin moisture content in the neck after 6 weeks and a significantly suppressed TEWL in the legs after 3 weeks.

This study builds on previous research that found supplementation with the salmon proteoglycan promoted the proliferate activity of human epidermal keratinocytes and dermal fibroblast, as well as the production of type I collagen and hyaluronic acid. Previous research also demonstrated that supplementation improved markers of skin sagging, wrinkles, and elasticity.

“This new research further strengthens the scientific substantiation of Juvecol, adding to the body of strong efficacy data for skin and joint health,” said Denis Alimonti, director of Maypro’s Proprietary Branded Ingredient Department, in a press release. “Given the ever-increasing problem of air-conditioning-caused skin drying, these findings could not come at a better time. We’re pleased that we are able to offer this award-winning and clinically-validated skin-health ingredient.”

Reference

1. Takahashi T et al. “Skin-moisturizing effect of an oral supplement containing salmon nasal cartilage proteoglycan.” Japanese Pharmacology & Therapeutics, vol 49, no. 3 (2021): 449-458