New LOAM prebiotic fiber formula includes NutriLeads’ Benicaros ingredient

In a recent press release, NutriLeads announced that their precision prebiotic called Benicaros, has been named as a key ingredient in a new supplement, LOAM Prebiotic Fiber Formula.¹ The product was created by LOAM founder Dr. Karan Rajan.

LOAM is a first-of-its-kind 6-in-1 formula which contains 10g of diverse prebiotic fibers per serving. This supplement may help support with mood, immunity, digestion, and metabolism.¹ The ingredient Benicaros is derived from upcycled carrot pomace which is also known scientifically as Rhamnogalacturonan-I (cRG-I). According to the press release¹, cRG-I “is a key component that increases beneficial gut bacteria consistently in all gut microbiome ecosystems—regardless of individual variations in microbiome composition.” Preclinical data has shown that Benicaros may help with protection of the gut barrier and a stronger immune response.¹

Benicaros was launched in the beginning of December 2025 and had a waitlist of almost 40,000 consumers.

“Benicaros aligns perfectly with LOAM mission to support healthier, more diverse gut microbiomes for beneficial overall health,” said Jan Jongsma, Chief Executive Officer of NutriLeads.¹ “Its clinically proven gut and immune health benefits, favorable formulation properties, and low gas formation compared to standard prebiotics, makes Benicaros an ideal fit for LOAM Prebiotic Fiber Formula.”

Clinical Trial Data

Published in Microorganisms in September 2025, the double-blind, placebo-controlled trial “Carrot Rhamnogalacturonan-I Supplementation Shapes Gut Microbiota and Immune Responses: A Randomised Trial in Healthy Adults,” demonstrates the modulating effects of Benicaros supplementation on gut microbiota, immune responses, and barrier function.² The study was funded by Eurostars.²

As the study explains, a high fiber diet is associated with reductions in risks for developing colorectal cancer, diabetes, cardiovascular disease, and obesity. Low fiber intake can result in less microbial diversity and a reduced presence of fermentation-derived metabolites, including short-chain fatty acids (SCFAs).² Researchers hypothesized that a relatively high dose over a short supplementation period would result in gut health benefits.

In this study, 54 healthy adult participants ages 18 -70 received either 500 mg/day of cRG carrot-derived rhamnogalacturonan-I (cRG-I), known as Benicaros, or placebo for four weeks. Particpants completed questionnaires on effects on gut health and well-being. In vitro and in vivo models evaluated the intestinal permeability. Weekly visits were conducted to collect measurements and data.

Bifidobacteria counts were assessed in both groups²:

• Increases in bifidobacteria counts increased gradually in the supplement group and peaked at a 1.5-fold increase in week 3
• By week 4, bifidobacteria counts increased by 43% in the placebo group and 57% in the supplement group

For microbial metabolites, only one statistically significant change was seen:

After four weeks, isobutyric acid was higher in the supplement group.

The health parameters questionnaires asked about gastro-intestinal symptoms, abdominal pain, reflux, indigestion, diarrhea, and constipation. Similar to the microbial metabolites, only one health parameter showed statistically significant changes²:

• At baseline, the diarrhea score was 4.50 ± 1.94 and reduced to 3.67 ± 1.2 after the supplementation

Additionally, an inflammation-induced gut barrier disruption model demonstrated that the supplement supported epithelial barrier integrity. The supplement also showed gut barrier protection support under stress-induced conditions.

Overall, the supplement was well-tolerated and no adverse events were reported from either group.² “These results support cRG-I as a safe, low-dose dietary intervention capable of beneficially modulating gut microbiota, immune responses, and barrier function in healthy adults within a short supplementation period,” the researchers concluded.

“This second clinical intervention study confirms gut and immune health benefits of Benicaros and strengthens the evidence for its additional role in protecting the gut barrier,” added Dr. McKay.²

References

1. NutriLeads’ precision Prebiotic Benicaros® featured in new loam prebiotic fiber formula https://nutrileads.com/news_events/news/nutrileads-precision-prebiotic-benicaros-featured-in-new-loam-prebiotic-fiber-formula/ (accessed Dec 11, 2025).
2. McEvoy, E. NutriLeads to present new Benicaros prebiotic fiber research on gut health and immunity at Supplyside Global 2025 https://www.nutritionaloutlook.com/view/nutrileads-to-present-new-benicaros-prebiotic-fiber-research-on-gut-health-and-immunity-at-supplyside-global-2025 (accessed Dec 12, 2025).