Elysium Health Launches Creatine+, a 3-in-1 Longevity System

The market positioning of creatine is undergoing a shift from a specialized sports performance supplement to a mainstream daily wellness intervention. Driven by recent clinical research into cellular energy metabolism and neuroenergetics, manufacturers are increasingly developing formulation strategies aimed at muscle preservation and cognitive support across diverse life stages. A reflection of this commercial shift is the launch of Creatine+ by Elysium Health, Inc., a finished product designed to address multiple biological pathways involved in long-term health and functional mobility.¹

Elysium highlights the loss of muscle mass, strength, and power in aging adults, which complicates long-term independence and physical resilience. "Over the last several years, creatine has evolved from a supplement primarily associated with athletes and gym-goers into one of the most widely popular interventions for healthy aging," stated Eric Marcotulli, CEO of Elysium. "That shift reflects a growing recognition that muscle health is one of the most important predictors of long-term health, independence, and quality of life.”

What Are the Formulation Highlights?

As noted in a recent feature article in Nutritional Outlook, while traditional creatine monohydrate is effective at supporting muscle energetics, it possesses distinct manufacturing and metabolic limitations.² It requires conversion within muscle cells before utilization, for example, and is prone to sedimentation and a gritty mouthfeel in finished products.

To optimize delivery, Elysium Health's proprietary system combines a micronized, high-purity creatine monohydrate with beta-hydroxy beta-methylbutyrate (HMB) and standardized pomegranate polyphenols. From a formulation perspective, micronization enhances the solubility and bioavailability of the raw material, the company explains, adding that the addition of HMB works to mitigate exercise-related muscle damage and prevent muscle loss, with data suggesting that the combination yields greater gains in lean mass and strength than creatine monohydrate alone.

The inclusion of standardized pomegranate polyphenols, which serve as precursors to urolithin A, targets mitochondrial renewal and cellular energy production.

"Creatine has become one of my favorite supplements for supporting the maintenance of lean body mass, strength, and performance as we age, especially when paired with consistent resistance training," stated Michael Fredericson, M.D, Co-Director of the Stanford Center on Longevity and Elysium Scientific Advisory Board member. "What's unique about Creatine+ is that it optimizes for two critical components of athletic performance—both output and recovery. I highly recommend creatine for men and women, but women especially face distinct changes in muscle physiology, and Creatine+ offers targeted nutritional support for maintaining performance and vitality." The creatine system was developed with the advisement of Dr. Fredericson, who is also Director of PM&R Sports Medicine at Stanford University.

How is Creatine Expanding Beyond Sports Nutrition?

The multi-ingredient mechanism in Creatine+ aligns with a broader industry trend toward optimizing the phosphagen energy system directly. Beyond physical recovery, ingredient suppliers are also focusing on neuroenergetics. Adenosine triphosphate (ATP) serves as the primary energy currency for the brain; when ATP recycling diminishes, cognitive function, memory, and neuronal resilience can be compromised. High doses of creatine monohydrate or low doses of creatine hydrochloride have been examined for their effect on brain energy metabolism.

Suppliers are also exploring alternative delivery systems to improve consumer adherence, including consumer-friendly formats, such as fast-melt powders, stable gummies, chewables, and clear effervescent beverages.

Additionally, emerging research positions creatine and HMB as viable adjunct therapies alongside glucagon-like peptide-1 (GLP-1) receptor agonists. One narrative review suggested that these ingredients help preserve lean muscle mass during pharmaceutical weight loss.³

As research and interest increases, creatine appears poised to continue to go beyond th active nutrition category and address healthy lifespan, brain energy, muscle preservation, and cellular resilience with accessible formats for consumers.

References

1. Elysium Health announces the launch of Creatine+, a first-of-its-kind longevity-focused creatine system designed to support strength, recovery, and cognition. PR Newswire. June 15, 2026. Accessed June 16, 2026. https://www.prnewswire.com/news-releases/elysium-health-announces-the-launch-of-creatine-a-first-of-its-kind-longevity-focused-creatine-system-designed-to-support-strength-recovery-and-cognition-302799866.html
2. Saraceno N. From sports performance to healthy aging, creatine finds new momentum. Nutritional Outlook. June 10, 2026. Accessed June 16, 2026. https://www.nutritionaloutlook.com/view/sports-performance-healthy-aging-creatine
3. Johnson BVB, Milstead M, Kreider R, Jones R. Dietary supplement considerations during glucagon-like peptide-1 receptor agonist treatment: a narrative review. Obes Pillars. 2025;16:100209. doi:10.1016/j.obpill.2025.100209