DuPont Researchers Liken EPA-Rich GM Yeast to GRAS Fish Oil

September 22, 2010

Research conducted by DuPont (Wilmington, DE) suggests that EPA oil derived from genetically modified yeast bears a safety profile 'comparable to that of [Generally Recognized as Safe] GRAS fish oil.' The study, published in the journal Regulatory Toxicology and Pharmacology, investigated the effects of EPA oil from genetically modified Yarrowia lipolytica. For 90 days, rats were assigned placebo; 98, 468, or 976 mg of the yeast; or GRAS fish oil daily by oral gavage.

Research conducted by DuPont (Wilmington, DE) suggests that EPA oil derived from genetically modified yeast bears a safety profile 'comparable to that of [Generally Recognized as Safe] GRAS fish oil.'

The study, published in the journal Regulatory Toxicology and Pharmacology, investigated the effects of EPA oil from genetically modified Yarrowia lipolytica. For 90 days, rats were assigned placebo; 98, 468, or 976 mg of the yeast; or GRAS fish oil daily by oral gavage.

In checking for cholesterol markers, lower total cholesterol and low-density lipoprotein (or 'bad' cholesterol) levels were noted in the medium and high yeast groups and fish oil group. High-density lipoprotein (or 'good' cholesterol') was lowered in the high yeast and fish oil groups only at early time points, note the researchers.

Regarding adverse health effects, nasal lesions were observed in rats fed high and medium yeast, and fish oil'”reportedly due to oil in the nasal cavities. Outside of this observation, no other side effects were reported.

'The safety profile of EPA oil was comparable to that of GRAS fish oil,' wrote the study...s lead author. 'These results support the use of EPA oil produced from yeast as a safe source for use in dietary supplements.'

To read the study...s abstract, click here.