Bonded Arginine Silicate More Bioavailable than Arginine and Silicon Individually, Study Suggests

July 7, 2016

Preclinical study results suggest Nitrosigine bonded arginine silicate complex significantly increases blood serum levels of arginine and silicon compared to equivalent doses of Nitrosigine’s components individually.

Nitrosigine, a bonded arginine silicate ingredient from Nutrition 21 (Purchase, NY) marketed for sports nutrition, men’s health, and cardiovascular health, appears to be considerably more bioavailable than just the sum of its parts.

Soon-to-be-published results of a 2015 preclinical study suggest Nitrosigine supplementation significantly increases blood serum levels of arginine and silicon compared to equivalent doses of Nitrosigine’s components individually, according to Nutrition 21.

In findings presented last month at the International Society of Sports Nutrition 13th Annual Conference, 28 rats were randomized to one of four groups: a control group, an arthritic control group, an arthritic experimental group supplementing with 1.81 g/kg/day of Nitrosigine, or an arthritic experimental group supplementing with equivalent doses of the separate component parts of Nitrosigine (arginine HCI, silicon, and inositol). The experimental period of the study lasted 29 days, with researchers analyzing blood samples and joint-tissue samples for arginine and silicon content.

The Nitrosigine group presented with significantly greater levels of serum arginine, serum silicon, joint-tissue arginine, and joint-tissue silicon than all the other treatment groups at day 29, including the group consuming arginine, silicon, and inositol as individual components, according to Nutrition 21.

“The results of this study demonstrate that the activity of the inositol-stabilized arginine silicate complex is different than activity seen with each of the individual components,” said James Komorkowski, Nutrition 21’s vice president of scientific and regulatory affairs. “As a result, the benefits seen in clinical studies are specific to the bonded complex.”

The study’s abstract is planned for publication in an upcoming issue of the Journal of the International Society of Sports Nutrition, said Nutrition 21.

 

Read more:

Nutrition 21’s Nitrosigine Sports-Performance Ingredient Now GRAS

L-Citrulline/L-Arginine Combination May Improve Circulation: Animal Study

 

Michael Crane
Associate Editor
Nutritional Outlook Magazine
michael.crane@ubm.com