In Vitro Study: Slimaluma May Prevent Fat-Cell Division

Brand name ingredient Slimaluma, an extract of Caralluma fimbriata, has been shown to inhibit pre-adipocyte cell division in a mouse cell study published in Food and Nutrition Sciences.

According to researchers, “CFE [Caralluma fimbriata extract] appears to inhibit pre-adipocyte cell division by interfering with a mechanism preceding the import of cyclin D1-CDk4/6 complex into the nucleus during the early G1 phase of the cell cycle, suggesting that CFE has the potential to inhibit hyperplastic obesity.”

They said that CFE inhibited 3T3-L1 cell growth in a dose- and duration-dependent manner, with the optimal dose appearing to be at or near 100 µm/ml. One of the researchers was Ramasamy Venkatesh of Gencor Nutrients (Anaheim, CA), the developer of Slimaluma.