Research examines effects of HMB supplementation for muscle support in older adults

In a recent press release, TSI Group commented on two recently published studies on the effects of the nutrient β-hydroxy β-methylbutyrate (HMB) on muscle loss in older adults. The studies offered research on dosing and duration as well as its potential use in sarcopenia.

“The global population is aging rapidly, and consumers are increasingly looking for proactive solutions to stay strong, mobile and independent. Brands must meet this shift head-on. Ingredients such as HMB, with clinically confirmed benefits, offer an incredible opportunity to deliver meaningful support to the 50+ demographic,” stated TSI Group vice president of business development Shawn Baier, MS, MBA, in the press release.

The first study¹, a meta-analysis, was published in April 2025 in Frontiers in Nutrition, and focused on the effects of dosing and duration of oral supplementation of HMB, an in vivo metabolite of leucine. Researchers analyzed 21 randomized controlled trials totaling 1935 participants, all over the age of 50. According to the abstract, improvements were seen in muscle mass, strength, and physical function, with a dose of 3 g per day showing improvements, and a dose of 3 g per day for more than 12 weeks being the dose and duration for enhanced benefits.

“This new meta-analysis validates what we at TSI have been championing for years: HMB is a scientifically proven ingredient that supports muscle health and function as we age,” stated Baier. “We’ve long understood the critical role HMB plays in addressing age-related muscle loss, and it’s rewarding to see the clinical community continue to affirm that.”

The second study² was published in Nutrients in April 2025 and examined nutritional treatments for sarcopenia, a condition chatacterized by skeletal muscle loss. Along with examining the mechanism of the onset of sarcopenia, plus dietary interventions and physical exercise, the study explored supplementation with HMB another synergistic support option. Noting that the recommended daily amount of HMB, 3 g per day, is challenging through diet alone, researchers stated that supplementation is necessary, especially for muscle recovery. The study also explained how HMB stimulates protein synthesis, has anti-inflammatory effects, and reduces oxidative stress. The prevention muscle loss can be beneficial during periods of physicals stress, immobilization and inactivity, plus chronic diseases, as well as sarcopenia in older adults, the researchers stated.

References

1. Li, N.; Chen, S.; He, Y.; Chen, Y.; Duan, X.; He, W.; Wang, Q.; Liu, S.; Liu, T.; Fang, H. Effects of oral supplementation of β -hydroxy-β -methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis. Front. Nutr. 2025. DOI: 10.3389/fnut.2025.1522287
2. Barone, M.; Baccaro, P.; Molfino, A. An Overview of Sarcopenia: Focusing on Nutritional Treatment Approaches. Nutrients. 2025. DOI: 10.3390/nu17071237