Preclinical data suggests two new bioactives found in hemp hulls may support gut barrier function

Preclinical data published in the Journal of Food Bioactives¹ found that two bioactives found in hemp hulls may support gut barrier function. The bioactives, N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT) were discovered by Brightseed, using its Forager AI platform.

During the in vitro study, proliferative human transverse colon epithelial cells were plated and co-cultured with tumor necrosis factor (TNF) along with NCT, NFT or NCT/NFT over a 48-hour. The addition of TNF was associated with a decrease in transepithelial electrical resistance (TEER) and increase in the intestinal permeability, while co-administration of NCT and NFT caused a dose-dependent and statistically significant reversal of impaired TEER and intestinal permeability.

“This publication is the latest validation of Brightseed’s approach to discover solutions in nature to restore human health,” said Jim Flatt, CEO and co-founder of Brightseed, in a press release. "These insights into how NCT and NFT can support gut function, and specifically gut barrier strength by restoring a healthy epithelium barrier, provide a strong foundation for the clinical research that is underway to substantiate the benefits of natural ingredients for personalized and proactive health solutions."

“We’re excited to continue applying these rigorous research insights to develop a portfolio of bioactive ingredients to meet important consumer health areas,” added Sofia Elizondo, COO and co-founder of Brightseed. “Brightseed’s focus on computational bioactive discovery paired with advanced metabolomics is enabling the functional food, beverage and dietary supplements industries to unlock the full potential of bioactives for human health.”

Reference

1. Bolster, D.; Chae, L.; Klinken, J.-W. van; Kalgaonkar, S. Impact of selected novel plant bioactives on improvement of impaired gut barrier function using human primary cell intestinal epithelium. Journal of Food Bioactives. 2022, 20. DOI: 10.31665/JFB.2022.18324