HTBA invests in new diosmin manufacturing plant in Spain

HealthTech Bio Actives (HTBA) announced in a recent press release the new construction of a diosmin production plant which will be located at their research, development, and manufacturing center in Murcia, Spain. The new production plant brings an investment of more than six million euros. With the new facility, HTBA will be able to increase their diosmin production capacity by more than 40%. Through the increase of production, pharmaceutical and nutraceutical manufacturers will be able to create future innovations with the ingredient.

Diosmin is known for its potential to help with vacular discomfort, circulation, and venous tone. According to the emailed press release, HTBA is the world’s largest producer of the ingredient and manufactures it as an active pharmaceutical ingredient (API) to be used in the treatment for chronic cardiovascular disease (CVD), hemorrhoids, spider veins, amd varicose veins. Additionally, diosmin is utilized as a food supplement ingredient called DiosVein.

“This latest investment further reinforces HTBA’s standing as an international leader in the production of flavonoids, supporting innovation in the health and wellness sector,” comments Alexandre Valls-Coma, Chief Executive Officer at HTBA. “By prioritizing innovation and sustainable manufacturing, over the last few years the company has entered a period of remarkable growth. This project further strengthens our expansion and competitiveness in a highly regulated and demanding global environment.”

HTBA participates in zero-waste sustainability through the utilization of solvent-free manufacturing for their diosmin ingredient. The press release mentioned that it “yields no remaining organic solvents and ensures compliance with the highest quality standards,” and is the only company using water as a solvent. With this option, HTBA was granted the Zero Waste certification by AENOR, which verifies that HTBA valorizes at least 90% of the waste it generates.

“We’re always striving to achieve better solutions and processes that improve manufacturing sustainability and efficiency while helping to support health and wellbeing,” explains Ignacio Paco Ferreira, Chief Operations Officer at HTBA. “Our new plant will not only increase production, it will also equip us to improve our operating model through research-driven process innovation, digitalisation, and energy efficiency. With improved and expanded production, we’re gearing up to better meet customer and consumer needs for the long-term, offering consistent, reliable supply as a trusted source of high-quality diosmin for nutraceutical and pharmaceutical applications.”

Earlier during the year, HTBA disclosed a prior 25-million-euro investment project involving the completion of their research, development, and manufacturing center located in Spain. The new state-of-the-art production plant, establishes HTBA as “the only company in Europe capable of producing all active forms of vitamin B12.”

HTBA Showcases Citrus Flavonoid and Vitamin B12 Innovations at SupplySide Global 2025

HTBA announced the innovations in taste modulation and functional health it would be showcasing at SupplySide Global, which took place during October 27-30, 2025, in Las Vegas, Nevada.¹ HTBA will be present at booth #7765 at the event. With a focus on active performance support, the company will showcase the sweet orange polyphenol extract Cardiose, the solvent-free diosmin DiosVein to support blood circulation and vascular comfort, and the MecobalActive, a pure form of vitamin B12.

“We’re gearing up to explore fresh opportunities with new and existing partners at SupplySide Global this year to meet evolving daily and active lifestyle needs,” stated Mauro Trevisani, HTBA’s general manager for North America and division manager for taste modulation solutions, in a September 30 press release. “As consumers become increasingly discerning, it’s no longer just about responding to trends. Instead, we’re focusing on collaborating with brands to define the next generation of nature-led, science-backed solutions that taste great and help consumers to feel mentally and physically better. Tapping into the potential of citrus flavonoids and green chemistry, our functional health and taste modulation solutions are truly designed to inspire innovation in this arena.”

Reference

1. McEvoy, E. HTBA to showcase citrus flavonoid and vitamin B12 innovations for active performance at Supplyside Global 2025 https://www.nutritionaloutlook.com/view/htba-to-showcase-citrus-flavonoid-and-vitamin-b12-innovations-for-active-performance-at-supplyside-global-2025 (accessed Dec 15, 2025).