2025 Brain Health Roundup

1. The science of brain maintenance: A neurologist's perspective

In this feature article from our April issue of Nutritional Outlook, neurologist Alexander Zubkov presents an integrative approach to long-term cognitive health, focusing on the most studied nutrients and herbs for brain health, when to start taking supplements, and the role of gut-brain connection.

“We now understand that brain health is deeply connected to what we consume,” Zubkov explains. “The neurons in our brain rely on a steady supply of essential nutrients, healthy fats, and antioxidants to function optimally. Deficiencies in key vitamins and minerals—such as B vitamins, magnesium, and omega-3 fatty acids—can impair neurotransmitter production and accelerate cognitive decline.”

He adds, “For those looking to maintain optimal cognitive health, the key is proactive maintenance. Whether through dietary changes, targeted supplementation, or lifestyle modifications, we all have the power to influence our brain’s longevity. And in the evolving field of neurology, I believe that embracing an integrative mindset will be the future of brain health care.”

2. Botanical nootropics and how they’re shaping the future of cognitive health innovation

Here, David DeSouza, president of Monterey Bay Herb Co., highlights popular nootropic herbs and strategies for formulating high quality and effective products that responsibly communicate benefits in line with federal regulations. He explains the leading botanicals in the category, sourcing and efficiency, and responsible marketing strategies.

“The rise of botanical nootropics signals a broader shift in how consumers approach mental performance,” he explains. “As the brain health category expands, natural ingredients offer a compelling foundation for products that align with both wellness goals and clean-label values. However, successful innovation depends on more than ingredient choice. Brands that commit to clinical rigor, responsible sourcing, and ethical storytelling will be best positioned to lead—and sustain—growth in the cognitive health space.”

3. Nutrition during adolescence: A missed opportunity for optimal cognitive health?

In this article, the Cognitive Health Committee of the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) explores the significant gap in knowledge about the impact nutrition has on adolescent cognitive development.

To highlight opportunities to learn more about the impact of nutrition during adolescence, the IAFNS committee initiated a systematic review, led by researchers at Swansea University, focused on a comprehensive age range of 8 to 19 years, author Marie Latulippe, MS, MBA, RDN explains. In total, 48 randomized controlled trials and 25 prospective cohort studies met the inclusion criteria. Because of lack of consistency across studies, it was difficult to discern the impacts of specific nutrients on cognition and academic achievement. There were beneficial effects for some nutrients such as Vitamin D, choline, polyphenols, and whole grains, but evidence was sparse. Although conclusions were elusive, this review points to a significant gap in knowledge about how nutrition can be impactful in adolescence.

4. Vitamin B12 on the brain: the growing popularity of B12 in cognitive health and beyond

In our January/February issue of Nutritional Outlook, Editor Madeline Colli explains how vitamin B12 is gaining steam in the cognitive health category and proving to be a supplement to watch. Colli spotlights the core mechanisms of the vitamin, consumer interest, the variety of its forms, and its growth in the market.

“The importance of vitamin B12 for human health, particularly cognitive health, is well established,” Colli explains. “Naturally, vitamin B12 is a valuable addition to these formulas as manufacturers combine herbs and proprietary ingredients with tried and true vitamins and minerals that speak to a basic understanding of nutrition.”

5. Emerging science on dietary supplements and brain health

In our March issue of Nutritional Outlook, Editor Sebastian Krawiec explores the role of nutrition in reducing the risk of age-related cognitive impairment, and why more research is necessary to validate claims and promote innovation, referencing multiple published research studies.

“Confidence in supplements and their cognitive health claims varies, with most medical professionals not putting much stock in them largely due to the lack of large clinical trial data validating these benefits,” Krawiec explains. “Many take issue with what they view as deceptive and predatory marketing since people already experiencing cognitive deficits are unlikely to see any measurable improvements. That is not to say that certain nutrients and herbs cannot support cognitive health, simply that more substantiation is required.”