Ganeden BC30 Supports Digestion, Immune Health in Seniors?

With 20 studies on probiotic strain Ganeden BC30 under the belt of Ganeden Biotech (Cleveland, OH), why not go for 21? Well, now Ganeden has.

On May 7, the company announced the results of the 21st study on Ganeden BC30, which explored the proprietary probiotic strain’s effects on digestive and immune health in healthy seniors. The study found that daily consumption of Ganeden BC30 (Bacillus coagulans GBI-30, 6086) significantly increased populations of Faecalibacterium prausnitzii-a strain of beneficial bacteria linked to gastrointestinal health-as well as reducing a cytokine linked to reduced inflammation throughout the body.

The double blind, placebo controlled, cross-over study involved 36 participants aged 65-80 in generally good health and free of any gastrointestinal illness. The participants were randomly assigned to receive either 1 billion CFU of Ganeden BC30 or a placebo to take in daily capsule form for 28 days. At the completion of the first treatment, participants underwent a 21-day washout period before switching to the other treatment for another 28 days. Blood and fecal samples were collected at the beginning and end of each treatment period.

Compared to the placebo treatment, researchers found that consumption of Ganeden BC30 led to a greater increase in populations of F. prausnitzii in participants. A blood analysis also revealed an increase in anti-inflammatory cytokine IL-10 after treatment with Ganeden BC 30, with no such effect observed after placebo treatment.

As a result of their findings, the researchers concluded that “daily consumption of BC30 by adults aged 65-80 [years] can increase beneficial groups of bacteria in the human gut and potentially increase production of anti-inflammatory cytokines.”

The same population of participants were also used in a previous in vitro study, which found that a combination of prebiotics and Ganeden BC 30 led to an greater increase in short chain fatty acids than when the prebiotics were consumed alone.

“Seniors have natural changes to the GI and immune system that are unrelated to illness, making them an ideal healthy population to study in order to show the benefits of a probiotic,” says David Keller, vice president of scientific operations, Ganeden Biotech. “This study in healthy adults supports both digestive and immune health claims for Ganeden BC30, and has helped us better understand how Ganeden BC30 can help with the effects of aging in the gut.”

Nyangale EP et al. “Bacillus coagulans GBI-30, 6086 modulates Faecalibacterium prausnitzii in older men and women.” The Journal of Nutrition. Published online May 6, 2015

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Michael Crane
Associate Editor
Nutritional Outlook magazine
michael.crane@ubm.com

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