UC-II Collagen Improves Joint Function in Healthy Subjects, New Study Shows

February 20, 2013

Subjects were first evaluated to confirm that they did not meet the American College of Rheumatology criteria for osteoarthritis.

UC-II, an undenatured type II collagen ingredient, significantly improved joint flexibility in healthy subjects, according to a new study presented at the 2013 Scripps Natural Supplement Conference. The conference took place in San Diego from January 31 to February 2, 2013. InterHealth Nutraceuticals (Benicia, CA), which supplies UC-II, says the research abstract will also be published in The Journal of Alternative and Complementary Medicine.

The randomized, double-blind, placebo-controlled study was conducted in 55 healthy subjects for 17 weeks. Subjects were first evaluated to confirm that they did not meet the American College of Rheumatology criteria for osteoarthritis. Joint flexibility was assessed by knee extension, and joint stress was induced via a standardized stemill protocol. Researchers concluded, “[S]upplementation with UC-II for 17 weeks was well-tolerated and more effective than placebo in supporting joint comfort, flexibility, and mobility.”

Additionally, UC-II was shown to significantly delay the onset of joint discomfort compared to baseline when exercising. It also accelerated the offset of joint discomfort compared to baseline after exercising.

Principle researcher Jay Udani, MD, CEO of Medicus Research, presented the UC-II results at the Scripps conference.

“The research results from this healthy population study not only represents great clinical findings in terms of UC-II and joint health, but represent a great marketing opportunity for dietary supplement manufacturers as well,” says Jay Martin, vice president of sales and marketing, InterHealth.