Synergistic formula supports inflammatory markers and blood pressure, says recent study

September 22, 2020

A recent study found a synergistic supplement formula containing mixed tocotrienols, curcumin, omega-3s, astaxanthin, and other nutrients significantly reduced inflammatory markers and systolic blood pressure in healthy subjects.

A randomized, double-blind, placebo-controlled clinical trial1 found a synergistic supplement formula containing mixed tocotrienols (EVNol, from ExcelVIte Inc., based in Edison, NJ), curcumin, omega-3s, astaxanthin, and other nutrients significantly reduced inflammatory markers and systolic blood pressure in healthy subjects.

A total of 80 healthy volunteers were enrolled and randomized to receive two Freedom Softgels (from Tischon Corp. Based in Westbury, NY) or a placebo twice daily for four weeks. The Freedom Softgels consisted of 500 mg of Cavacurmin (from Wacker, based in Munich, Germany), 675 mg of omega 3 (450 mg EPA + 100 mg DHA + other omega 3's 125 mg), 3 mg of astaxanthin, 9.5 mg of gamma-linoleic acid (GLA), 12.5 mg of mixed-tocotrienols (EVNol), 6.25 mg of hydroxytyrosol, 1000 IU of vitamin D3, and 12.75 mg of potassium.

After four weeks, compared to the placebo, the treatment group saw a significant reduction of systolic blood pressure. There was also an improvement in endothelial function and a significant decrease of inflammatory biomarkers IL-6 and hsCRP.

“Tocotrienol possess diverse unique biological activities like antioxidant, anti-inflammatory and anti-aging properties,” sad Bryan See, business development manager of ExcelVite, in a press release. “This synergistic COMBO of antioxidants and cardio-protective ingredients like curcumin, EPA, astaxanthin, tocotrienol and other nutrients, helps promote healthy cardiovascular function and other health benefits (such as better immune response) via its superior antioxidant and anti-inflammatory functions.”

“Dietary supplements have received considerable interest due to potential nutritional, safety and therapeutic effects,” said Raj Chopra, PhD, CEO of Tishcon, in press release. “This trial validates that Freedom softgels containing Cavacurcumin, omega 3, astaxanthin, GLA, with vitamin D, EVNol, and hydroxytyrosol exhibits anti-inflammatory and antioxidant properties. Such observations highlight the importance and growing need for accessible and effective anti-inflammatory and anti-hypertensive interventions.” 

Reference

  1. Birudaraju, D et al. “A combined effect of Cavacurcumin, Eicosapentaenoic acid (Omega-3s), Astaxanthin and Gamma -linoleic acid (Omega-6) (CEAG) in healthy volunteers- a randomized, double-blind, placebo-controlled study” Clinical Nutrition ESPEN, vol. 35 (2020): 174-179