The boswellia extract was found to significantly improve knee pain in healthy adults in a new study, possibly by inhibiting secretion of hyaluronic acid into the blood.
Boswellin Super, a Boswellia serrata extract from Sabinsa (East Windsor, NJ), was found to alleviate knee pain in healthy Japanese adults in a new study. Results of the randomized, double-blind, placebo-controlled trial, published in The European Journal of Biomedical and Pharmaceutical Sciences, also suggest the boswellia extract inhibited secretion of hyaluronic acid into blood.
The study included 47 healthy adult subjects with knee pain who were randomized to consume a daily capsule containing either 100 mg/day of Boswellin Super or a placebo for eight weeks. Participants in the boswellia group had a mean age of 48.2 +/- 10.9, while participants in the placebo group had a mean age of 49 +/- 9.8 years. Researchers measured participant knee pain at baseline, four weeks into the intervention, and eight weeks into the intervention with three primary outcome measures: the Visual Analog Scale (VAS), the Japanese Knee Osteoarthritis Measure (JKOM), and the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC). Additionally, researchers measured serum hyaluronic acid and high sensitive C-reactive protein of participants.
After eight weeks of intervention, the group consuming Boswellin Super showed significant improvements to the VAS, JKOM, and WOMAC scores compared to baseline. Additionally, serum hyaluronic acid levels were found to be lower in the boswellia group than the placebo group after 8 weeks of intervention.
“Although the variation within each group was not significant, the mean serum hyaluronic acid level in the [Boswellin Super] group decreased while that in the placebo group increased,” researchers noted. “Therefore, these results suggest that the B. serrata extract may inhibit hyaluronidase activity, which in turn suppresses the outflow of hyaluronic acid to serum.” They added that knee-joint paint “could be correlated with high serum hyaluronic acid levels.”
Based on the findings, researchers concluded that Boswellin Super “could find potential use to relieve knee-pain patients and manage related inflammatory conditions.”
Nutritional Outlook Magazine
Majeed M et al., “Effect of Boswellin Super on knee pain in Japanese adults: a randomized, double-blind, placebo-controlled trial,” European Journal of Biomedical and Pharmaceutical Sciences, vol. 3, no. 10 (November 2016): 293–298