Curcumin phytosome ingredient from Indena may support kidney health, says recent study

Photo © Shutterstock.com/ COLOA Studio

A recent study¹ found that a proprietary curcumin phytosome from Indena (Milan, Italy), called Meriva, may be an effective modulator of oxidative stress to support kidney detoxification and filtering function. In the pilot study, 24 patients with chronic kidney disease (CKD) were given 500 mg of Meriva twice per day for three to six months, and 20 healthy volunteers were recruited for control. Subjects taking Meriva were evaluated at baseline, three months, and six months for uremic toxins, metagenomic of gut microbiota, as well as nutritional, inflammatory, and oxidative status.

Results showed that supplementation significantly reduced plasma pro-inflammatory mediators such as CCL-2, IFN-γ, and IL-4, and lipid peroxidation. After six months, researchers also observed that supplementation resulted in a more balance composition of the gut microbiome with significantly lower levels of Escherichia-Shigella, and significantly higher Lachnoclostridium. At three months, researchers also noted significantly higher levels of Lactobacillaceae spp. at the family level. No adverse events were observed in subjects taking Meriva.

Reference

1. Pivari F et al. “Curcumin supplementation (Meriva) modulates inflammation, lipid peroxidation, and gut microbiota composition in chronic kidney disease.” Nutrients, vol. 14, no. 1 (January 5, 2022), https://doi.org/10.3390/nu14010231