Biothera, USP Develop First Monograph for Beta-Glucan

September 19, 2011

The monograph has been published in the Third Supplement of the Seventh Edition of USP’s Food Chemicals Codex.

The United States Pharmacopeia (USP), in collaboration with Wellmune WGP beta-glucan ingredient supplier Biothera (Eagan, MN), has developed the first official monograph for beta-glucan derived from bakers yeast (Saccharomyces cerevisiae), which is widely promoted for its immune-health benefits.

The monograph has been published in the Third Supplement of the Seventh Edition of USP’s Food Chemicals Codex, which serves as a compendium of standards for the purity and identity of food ingredients.

Biothera contributed its reference standard and two methods for identifying and quantifying the beta 1,3/1,6 branched glucan polymer derived from the cell walls of bakers yeast, as well as additional methods for ensuring material purity. The Biothera identification method uses Nuclear Magnetic Resonance Spectroscopy to detect glucan branch linkages. To quantify the purity of the beta-glucan content, Biothera developed a Glucan Enzymatic Method (GEM) assay, which was recently published in the ACS Journal of Agricultural and Food Chemistry.

“We are pleased the USP recognized the technical merit of our analytical methods, and validated and adopted our analytical methods as part of the new monograph,” stated Andy Magee, PhD, Biothera’s vice president of chemistry.

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