Study finds Lipofer iron supplement boosts absorption without GI discomfort

Lubrizol announced it will showcase its microencapsulated iron ingredient Lipofer at SupplySide Global at booth #4523, October 29-30, 2025, in Las Vegas, Nevada. The proprietary formulation is highly concentrated and micronized, and its controlled release is intended to provide a source of iron without gastrointestinal side effects seen in conventional iron sources.¹ Lubrizol will also be present at CPHI in Frankfurt, Germany at booth #8M71 on October 28-30.

Study examines Lipofer’s role in reversing iron deficiency

The efficacy of Lipofer in reversing diet-induced iron deficiency was tested in an in vivo animal study, “Comparative study of the effects of different iron sources on bioavailability and gastrointestinal tolerability in iron-deficient rats,” which was published in Scientific Reports in July 2025.² As the study explains, iron deficiency anemia, characterized by a lack of red blood cells and reduction of blood’s ability to carry oxygen, affects millions of people globally, yet conventional iron sources can cause gastrointestinal side effects. The side effects include nausea, vomiting, and constipation, which can reduce the efficacy of iron supplementation.

This study was conducted with iron-depleted rats, which were given iron supplementation treatments with different iron sources: Lipofer (Def-LFe1), ferrous bisglycinate, and a commercially available microencapsulated iron pyrophosphate (Def-Fe2). Other sources of iron supplements were used for comparison. After the iron deficiency was reversed, the tolerability of the supplements was examined for nine weeks.

Improved absorption and fewer side effects observed

All three supplements reversed iron deficiency in 14 days without side effects, but during the nine-week supplementation period, the rats given Lipofer showed fewer side effects and a higher absorption rate.

• Rats given ferrous sulfate (FeSO4, the most common treatment for iron-deficiency anemia) demonstrated a lower body weight gain, lower feed efficiency, and other parameters. These parameters were not seen in test group given Lipofer.
• The Lipofer group also demonstrated greater body weight gain and higher feed efficiency than other groups
• A higher absorption rate in the Lipofer group was demonstrated through higher hemoglobin and lower total iron binding capacity (TIBC) levels
• Gastrointestinal side effects were not seen in the Lipofer group

Ultimately, the results showed Lipofer to be a potential alternative to conventional iron supplements. “This study has highlighted the ability of the LIPOFER™ technology to be an effective product for reversing iron deficiency while minimizing any unwanted side effects frequently reported for other iron supplements,” the researchers concluded.

Microencapsulation technology enhances bioavailability

“The microencapsulation matrix we’ve developed ensures that iron is delivered in a controlled manner,” stated Isabel Gómez, global marketing manager for Lubrizol Nutraceuticals, in the October 16 press release. “This not only improves tolerability but also enhances the bioavailability of the mineral, as confirmed by the study’s hematological and biochemical markers. This study reinforces our commitment to developing science-driven, consumer-preferred solutions that address real nutritional challenges. Iron deficiency continues to affect billions globally, and our microencapsulated iron ingredient offers a breakthrough in both efficacy and comfort.”

Additionally, the press release explains, absorption of nutrients is supported by lecithin in the microcapsules, as well as the large surface area of the iron particles, which also helps the iron in reaching the intestine without side effects.

“These findings are a testament to the importance of formulation science in addressing micronutrient deficiencies,” adds Alan Connolly, Global R&D Manager. “By improving both the absorption and the user experience with great-tasting iron supplements we’re bridging the gap between clinical efficacy and consumer adherence.”

Applications in supplements and functional foods

Lipofer is delivered in pill form and a water-dispersible powdered stick, enabling application in dietary supplements and functional food and beverages, including a pectin-based gummy.

References

1. Mariné-Casadó, R., Tobajas, Y., Antolín, A. Negra, T.; Connolly, A.; Alcaide-Hidalgo, JM.; Caimari, A. Comparative study of the effects of different iron sources on bioavailability and gastrointestinal tolerability in iron-deficient rats. Sci Rep. 2025. 15, 21033. DOI: 10.1038/s41598-025-07202-3
2. Lubrizol. Lubrizol’s Microencapsulated Iron Outperforms in Absorption and Gut Tolerance. October 16, 2025. (accessed 2025-10-17).