Lemme Enters Longevity Category With NAD+ and Skin Radiance Combination Formula

Lemme has introduced Lemme NAD+, the women's wellness brand's first supplement targeting the aging process directly, combining nicotinamide mononucleotide (NMN) with a patented antioxidant ingredient positioned for skin appearance.¹

The launch places Lemme in a longevity supplement category that has grown quickly in recent years. Recent reviews of the clinical evidence have found that NAD+ decline with age is not uniformly observed across all human tissue types, a nuance that differs from how the premise is often presented in category marketing.

"Women are thinking about longevity differently than they were even a few years ago," said Simon Huck, co-founder of Lemme. "There has been tremendous innovation around longevity, but very little that connects the science of healthy aging with healthy-looking skin. We saw an opportunity to create a more multidimensional formula, combining clinically studied NMN to support the body's natural NAD+ production with ingredients that also support healthy-looking skin."

What Does the Formula Actually Contain, and Why Choose NMN Specifically?

The formula centers on NMN, a precursor compound the body converts into nicotinamide adenine dinucleotide, a coenzyme involved in cellular energy metabolism.

"Taking NAD+ directly isn't the most effective approach because the molecule breaks down before it can reach your cells," said Dr. Kathleen Valenton, board-certified OB/GYN and chief medical officer at Lemme. "That's why we formulated Lemme NAD+ with clinically-studied NMN instead. NMN is the direct precursor your body converts into NAD+, and it sits one enzymatic step closer to NAD+ than other precursors on the market."

The formula also includes resveratrol, a plant-derived antioxidant, Yüth Spermidine, and Lutemax SkinGlo, a patented, dermatologist-tested antioxidant blend the company says is formulated to support skin brightness and tone.

How Settled Is the Science Behind NAD+ Decline and Supplementation?

The press release states that NAD+ levels may decline by as much as 50% with age, a figure commonly cited across the category. However, a 2025 review in Nature Metabolism examining the clinical evidence for age-related NAD+ decline in humans found that a consistent decline has only been reliably observed in certain tissues and contexts, with evidence in other tissues, including whole blood, remaining mixed or contested.²

A separate 2026 study published in the same journal similarly found that whole-blood NAD+ levels remained stable across age in multiple cohorts, challenging its use as a straightforward biomarker of aging.³ On the supplementation side, a systematic review of 10 randomized controlled trials evaluating NMN specifically found general associations with improved physical performance measures, though the review's authors noted the evidence base remains limited in scope, with most trials lasting under 12 weeks.⁴

Why Are Longevity and Beauty-From-Within Claims Increasingly Being Combined in One Formula?

Pairing internal healthy-aging ingredients with skin-focused antioxidants in a single formula reflects a broader trend across the beauty-from-within and nutricosmetics category, where consumer interest increasingly spans both internal health markers and visible appearance outcomes in the same purchasing decision.

Formulating for both goals in 1 capsule introduces its own tradeoffs, since ingredients selected primarily for skin-related outcomes, like Lutemax SkinGlo, are not necessarily studied for the same internal aging mechanisms NMN and resveratrol are positioned to address, meaning the formula's overall substantiation is likely a composite of several distinct research bodies rather than a single unified data set.

References

1. Lemme enters the longevity category with Lemme NAD+, a first-of-its-kind formula for healthy aging and skin radiance. PR Newswire. August 7, 2026. Accessed August 11, 2026. https://www.prnewswire.com/news-releases/lemme-enters-the-longevity-category-with-lemme-nad-a-first-of-its-kind-formula-for-healthy-aging-and-skin-radiance-302845654.html

2. Vinten KT, Trętowicz MM, Coskun E, et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nat Metab. 2025;7:1974-1990. doi:10.1038/s42255-025-01387-7

3. Whole-blood NAD+ levels do not reflect healthy ageing. Nat Metab. 2026;8:1260-1261. doi:10.1038/s42255-026-01540-w

4. Wen J, Syed B, Kim S, et al. Improved physical performance parameters in patients taking nicotinamide mononucleotide (NMN): a systematic review of randomized control trials. Cureus. 2024;16(8):e65961. doi:10.7759/cureus.65961