Frutarom Health’s Portusana was found to induce translocation of glucose transporter protein type 4, which may help decrease elevated blood glucose levels in diabetes patients.
Frutarom Health (Haifa, Israel) has shared new study results suggesting its Portusana purslane herb (Portulaca oleracea L.) extract may improve glucose uptake-offering further evidence for its potential anti-diabetic properties. In vitro models revealed that the purslane extract induced translocation of glucose transporter protein type 4 (GLUT4), which is considered a key aspect in decreasing elevated blood glucose levels in diabetes patients, Frutarom explains.
A team of researchers at the University of Applied Sciences Upper Austria (Wels, Austria), led by Julian Weghuber, PhD, studied the GLUT4 translocation–inducing properties of seven different plant extracts. Insulin sensitive CHO-K1 cells and adipocytes were treated with the plant preparations, and researchers used total internal reflection fluorescence (TIRF) microscopy to quantify GLUT4 translocation. Of the seven extracts studied, two were found to induce GLUT4 translocation-purslane and tindora (Coccinia grandis).
Researchers also used atomic force microscopy to prove complete plasma membrane insertion of these two extracts, which also suggested a “compound-mediated distribution of GLUT4 molecules in the plasma membrane similar to insulin-simulated conditions.” Additionally, the study incorporated a fluorescent actin marker to find that that purslane and tindora appeared to impact actin remodeling as observed in insulin treated cells. And beyond the in vitro models, there was also an in ovo aspect of the trial that suggested both tindora and purslane significantly reduced blood glucose levels in a chicken embryo.
“In conclusion, this study confirms the anti-diabetic properties of tindora and purslane, which stimulate GLUT4 translocation in an insulin-like manner,” researchers concluded. They also noted that due to the “lack of pharmaceuticals that specifically increase the uptake of glucose from the blood circuit,” these results may come as especially welcome news to the diabetic research community.
“This breakthrough research proves that purslane extract could be efficient in supporting healthy blood glucose levels,” says Virginie Codran, product manager for Frutarom Health. “Purslane is back by multiple research studies that support the findings of the study led by Julian Weghuber. This study confirms the positive effects of Portusana itself.”
Nutritional Outlook Magazine
Stadlbauer V et al., “Biomolecular characterization of putative antidiabetic herbal extracts,” PLoS One, vol. 11, no. 1 (January 2016): e0148109