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According to Studies, the Anti-Oxidant Ergothionine (MitoPrime® ) Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages.
December 6th, 2021Nanjing China---The star ingredient of NNB Nutrition (https://nnbnutrition.com/) MitoPrime®, dubbed as "longevity vitamin", a naturally-occurring amino acid found in low amounts in some foods and in high amounts in mushrooms which is characterized by its antioxidant property. A study investigates the immune-enhancing properties of EGT, and finds that it acts as a potentiator of toll-like receptor (TLR) signaling. EGT is also an immune modifier as well as a redox controller under TLR stimulation that induces M1 macrophages and a Th17 shift in inflammation.
During the past 2 years, the global impact of COVID-19 and its evolving mutant strain has been unprecedented and staggering. There has been a surge in demand for immune-health supplements amid the pandemic. The global immune health supplements market size was USD 18.22 billion in 2020. Based on the analysis of Fortune Business Insights, the global market exhibited a considerable growth of 11.6% in 2020 as compared to the average year-to-year growth during 2017-2019. This huge effect has weaved its way into every trend of supplement industry and impacted consumers’ choice.
Meanwhile, study (PMC5256913) shows that EGT affects cell survival and plays a part in inhibition of JNK-mediated IL-6 and TNF-α-mediated IL-8 production. EGT appears to suppress immune cell activation by acting on mitochondria in conjunction with its anti-oxidant function. Besides, EGT is an immune modifier as well as a redox controller under TLR stimulation that induces M1 macrophages and a Th17 shift in inflammation.
Ergothioneine And Immunity
Targets Cells in All 5 of the Body’s Immune Centers Studies show how Ergothioneine protects whole body immune cells, including in the body’s 5 immune centers: lymph nodes, appendix, gut, bone, thymus
May Strengthen Innate and Adaptive Immune Systems Studies show how Ergothioneine strengthens both the Innate Immune System and the Adaptive Immune System. But this has not yet been clinically proven.
May Increase the Body’s Immune Cell Activity Studies prove that Ergothioneine increases the activity of immune cells such as macrophages, lymphocytes, and NKC natural killer cells. Ex vivo only.
Speeds Up Immune Response Time Ergothioneine potentiates toll-like receptor signaling on macrophage surfaces, providing greater and faster recognition of pathogens. Ex vivo only.
Ergothioneine And Anti-Inflammatory
EGT reduces chronic inflammation and inhibits ‘root cause’ inflammation
“Senescent cells cause inflammation. Inflammation leads to medical frailty.” says Mayo Clinic, a nonprofit American academic medical center focused on integrated health care, education, and research.
EGT inhibits the synthesis of pro-inflammatory cytokines, interleukin IL-6 and IL-8.
MitoPrime exerted anti-inflammatory activity with its inhibitory effectson lysine chloramine formation induced by HOC.
Pre-treatment of 3T3-L1 cells for 2h with Ergothioneine significantly inhibited the TNF-α-induced IL-6 release.
EGT modulates inflammatory responses induced by treatment of cells with H2O2, tumor necrosis factor-α, or palmitic acid helps remove senescent cells and increases cell viability 45%.
Ergothioneine And COVID-19
Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against partial respiratory dysfunction and neuronal damage, prevent endothelial dysfunction, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in improving health status of people infected with COVID-19.
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