The study design aims to assess the safety and efficacy of tocotrienols for lipid-related parameters in obese postmenopausal women.
Photo © iStockphoto.com/hidesy
According to a paper published in BMJ Open, annatto tocotrienol’s potential anti-obesity effects are to be evaluated in post-menopausal women. The study design aims to assess the safety and efficacy of tocotrienols for lipid-related parameters in obese postmenopausal women. The six-month randomized, double-blind, placebo-controlled trial will be conducted at Texas Tech University Health Sciences Center and will utilize DeltaGold® annatto-derived tocotrienol by American River Nutrition (Hadley, MA). This will be the first-ever tocotrienol clinical trial on an obese population.
In the six-month study, approximately 60 postmenopausal women will be recruited and randomized to receive either a placebo or 300 mg/d of DeltaGold tocotrienol. The primary outcome measure will include determination of total/regional fat mass and visceral adipose tissue, with secondary outcomes measuring changes in the lipid profile, metabolism-related gene expression, fatty acid metabolites, and the gut microbiome.
“[I am] pleased to see this first-ever tocotrienol clinical trial on an obese population commence,” said Barrie Tan, PhD, president of American River Nutrition, in a press release. “This study attempts to quantify the role of tocotrienol in human adiposity in novel ways, measuring not only the mount of adipose tissue, but also adipose tissue bioavailability, adipose inflammation, and weight loss.”
Aryaie A. et al. “Actions of annatto-extracted tocotrienol supplementation on obese postmenopausal women: study protocol for a double-blinded, placebo-controlled, randomised trial” BJM Open, vol. 10, no. 3 (2020)
Cracking the code: Advancements in calcium absorption and nutritional understanding
July 23rd 2024Recent research conducted by ILSI U.S. and Canada – a global, nonprofit federation dedicated to advancing precompetitive research in the food, nutrition and health realms – and partially funded by Balchem, has shed light on how to improve predictions of Ca bioavailability across different food matrices.
New study shows that vitamin K2 as MK-7 may have neuroprotective qualities
May 17th 2024Researchers examined the effects of MK-7 and menaquinone-4 (MK-4) on neuroblastoma cells to understand how different forms of vitamin K2 impact the expression of genes involved in neurodegeneration and neuroinflammation.