A recent study found that a standardized ashwagandha extract (Witholytin from Verdure Sciences) helped reduce perceived stress and fatigue in men and women.
A recent study1 found that a standardized ashwagandha extract (Witholytin from Verdure Sciences) helped reduce perceived stress and fatigue in men and women. In the two-arm, parallel-group, 12-week, randomized, double-blind, placebo-controlled trial, 111 overweight or mildly obese men and women between the ages of 40 and 75 years took either 200 mg of ashwagandha or placebo twice daily for 12 weeks.
Results showed that supplementation with the ashwagandha extract was associated with a significant reduction in stress, based on the Perceived Stress Scale, but this reduction was not statistically significant compared to placebo. Ashwagandha consumption was also associated with a significant reduction in fatigue symptoms based on the Chalder Fatigue Scale, compared to placebo, as well as a significant increase in heart rate variability. Among men, those taking ashwagandha saw a significant increase in blood concentrations of free testosterone and luteinizing hormone, compared to placebo.
“We were very excited to see these hormone biomarkers,” explained Kristen Marshall, digital marketing manager, Verdure Sciences, in a press release. “Many formulations targeting men and women have prioritized adaptogens, as have fortified functional foods and beverages, and Witholytin is well suited to grow in these areas with this research.”
“We are excited to have this new publication join the evidence in support of Witholytin and our mounting body of evidence for ashwagandha extract standardization to USP methodology,” added Verdure Sciences’ executive vice president, Sonya Cropper. “Tremendous interest continues to build for ashwagandha, adaptogens, fatigue, energy, and mental vitality.”
Smith, S.J.; Lopresti, A.L.; Fairchild, T.J. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. Journal of Psychopharmacology, 37(11). DOI: 10.1177/02698811231200023