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Authors

 (Edgewood, MD), Brian Cornblatt, PhD, designs 

 and clinical studies for products and summarizes supporting research.

OmniActive Health Technologies (Bridgewater, NJ and Mumbai, India) has announced a partnership with the Council for Responsible Nutrition (CRN; Washington, D.C.) to educate and raise awareness about the role of lutein and zeaxanthin in supporting maternal and fetal health during pregnancy among obstetricians, gynecologists, and other maternal healthcare practitioners. This knowledge will be shared at The American College of Obstetrics and Gynecology’s (ACOG) Annual Clinical & Scientific Meeting. OmniActive is 

one of six companies CRN has partnered with

 to showcase the latest research and developments in prenatal nutrition through a specially designed “Prenatal Nutrition Center” at the conference. 

“It’s wonderful to have OmniActive as one of our featured partners during the ACOG annual event to help spread the word on the importance of prenatal nutrition,” said Andrea Wong, PhD, senior vice president, Scientific & Regulatory Affairs for CRN, in a press release. “CRN continues our efforts in supporting supplement manufacturers and ingredient suppliers in bringing clinically studied products to consumers to help meet their nutritional needs. Advancing awareness at the physician’s level is a huge part of this equation and this meeting is an effective way of reaching them.”

Citing market research from SkyQuest Technology, OmniActive explains in its press release that prenatal supplement sales were estimated to be at $740 million in 2023 and projected to rise to $1.4 billion by 2031. Similarly, a recent 

 found that about 60% of gynecologists think that 80-100% of their pregnant patients take dietary supplements. There is therefore a great deal of opportunity to grow and advance this category. Lutein and zeaxanthin are known for their support of eye health, but these benefits are relevant during pregnancy as well, says Deshanie Rai, PhD, FACN, vice president of Global Science, Regulatory and Advocacy at OmniActive Health Technologies.

“Current evidence supports the preferential accumulation of lutein and zeaxanthin in the human eye and neural tissues during pregnancy, especially during the third trimester. This suggests that lutein may play a functional and protective role in infant visual and cognitive development. As part of our Lutein for Every Age campaign, our goal is to help educate healthcare practitioners on this latest nutritional science research and the benefits of achieving adequate dietary lutein during pregnancy,” said Rai, in a press release. “OmniActive is proud to partner with the CRN Foundation’s Prenatal Nutrition Centre to promote awareness among healthcare practitioners on the nutritional relevance of lutein for both mom and baby.”

The educational initiative, “Lutein for Every Age,” focuses on raising awareness of early and consistent lutein and zeaxanthin intake to help support eye, cognitive, and general health throughout life, explains OmniActive. The AOCG meeting is taking place from May 17-19, 2024 in San Francisco, CA.

OmniActive Health Technologies has announced a partnership with the Council for Responsible Nutrition to educate and raise awareness about the role of lutein and zeaxanthin in supporting maternal and fetal health during pregnancy among obstetricians, gynecologists, and other maternal healthcare practitioners. 

Topic

OmniActive partners with CRN to raise awareness about macular carotenoids for prenatal health

You may have heard of the low-FODMAP diet as it relates to people with gastrointestinal conditions such as irritable bowel syndrome (IBS). FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides and polyols. These are short-chain carbohydrates (ie. sugars) that are poorly absorbed in the small intestine and can cause digestive distress, including symptoms such as cramping, diarrhea, bloating, constipation, and gas.

High-FODMAP foods include dairy, wheat, beans and lentils, some vegetables such as artichokes, asparagus, onions, and garlic, as well as some fruits such as apples, cherries, pears, and peaches. The idea of the low-FODMAP diet is to eliminate high-FODMAP foods from one’s diet for a period of two to six weeks to allow symptoms to go down and reduce small intestine bacterial overgrowth, if you have it.

 However, some of these foods should be slowly reintroduced to identify which ones trigger symptoms and which ones do not. This allows people to avoid the foods that cause gastrointestinal symptoms while continuing to eat foods that do not. Ideally, this process should be done under the supervision of a medical professional.

The reason that a low-FODMAP diet should be a process of temporarily elimination followed by reintroduction of high-FODMAP foods is because: 1) It would be a highly restrictive diet overwise, and 2) Fermentable carbohydrates feed bacteria in the gut, and eliminating them entirely may have a negative impact on the composition of one’s gut microbiome.

 For example, research does indicate that the elimination of high-FODMAP foods could lead to reduction in 

, which is well-recognized as a health-promoting gut bacteria. More research is necessary to understand the impacts a low-FODMAP diet has on the gut microbiome, but it is broadly accepted that it is effective for alleviating negative symptoms and improving quality of life for people with IBD or IBS. One review indicates that reduced FODMAP intakes do not impact bacterial diversity, but rather total bacterial abundance, and promotes a balanced approach to reduce negative gastrointestinal symptoms while also maintaining a healthy microbiome.

 This is often referred to as a “FODMAP-gentle” approach.

Products marketed and certified as low-FODMAP offer certain consumers peace of mind when they’re shopping for finished products. While they know what FODMAP ingredients they can or cannot eat, checking the labels of all food packaging is profoundly tedious. Certified products allow consumers to more safely shop for finished products while otherwise controlling what high-FODMAP foods they can include in their diet. There are currently two low-FODMAP certifications. One is theMonash University Low FODMAP Certified badge and the other is the FODMAP Friendly logo, both of which also have an app to help consumers find certified products.

People who suffer from IBS may benefit from other interventions besides a low-FODMAP diet alone and should consult a physician before pursuing one, but brands who want to capture a growing base of consumers may benefit from producing and certifying low-FODMAP products. For example, it’s estimated that IBS impacts up to 15% of the U.S. population, and affects women twice as often as men.

 However, because not everyone seeks medical care, up to 75% of cases may go undiagnosed.

 As more consumers seek help for their gastrointestinal symptoms, low-FODMAP foods may offer a measure of relief as well as answers to their digestive health issues.

FODMAP Diet: What You Need to Know. Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/wellness-and-prevention/fodmap-diet-what-you-need-to-know (accessed 2024-08-26).

Syed, K.; Iswara, K. Low-FODMAP Diet. StatPearls. 2023. https://www.ncbi.nlm.nih.gov/books/NBK562224/ (accessed 2024-08-26).

Halmos, E.P.; Gibson, P.R. Controversies and reality of the FODMAP diet for patients with irritable bowel syndrome. J Gastroenterol Hepatol. 

Irritable Bowel Syndrome (IBS). Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/conditions-and-diseases/irritable-bowel-syndrome-ibs (accessed 2024-08-26).

Ko, E.; Glazier, E. IBS is common, but still may be underdiagnosed. UCLA Health. December 31, 2021. https://www.uclahealth.org/news/article/ibs-is-common-but-still-may-be-underdiagnosed (accessed 2024-08-27).

Understanding FODMAPs and how low-FODMAP diets are implemented.

What is a low-FODMAP diet?

According to a recent press release (1), Health Canada recognized a functional claim authorization for SynbÆctive Femme (Femme), which is a “patented probiotic combination featuring 

 BL050, specifically focused on women’s urogenital health.”

The press release discusses the importance of urogenital health and how it can aid in the prevention of infections for example, bacterial vaginosis. It is estimated that about 30% of women experience this condition (1). By focusing on urogenital health, these measures can help lower the risk of various chronic conditions, benefit long-term health, and aid in overall wellbeing (1).

The Femme formulation has undergone three clinical studies that highlighted it’s women’s health benefits. Mentioned in the first study, the research showed that the strains in Femme had succeeded in colonization, migrated from the intestinal tract, and prevailed in the vaginal environment (1). An additional study disclosed how Femme’s probiotic formulation lowered the risk of occurrence for bacterial vaginosis, as well as encouraged “healthy vaginal microbiota” (1). More research showed that after 28 days (1), menopausal women experienced robust anti-inflammatory properties, improved vaginal health, and a rise in lactobacilli.

As mentioned in the press release (1) Femme strains were authorized for the following urogenital claims:

Helps support feminine and digestive health

Helps naturally maintain/support feminine health

Clinically shown to help support vaginal health

“We are thrilled that an institution as rigorous as Health Canada has recognized the quality and scientific value of Femme,” Cristiana Piangiolino, Managing Director of SynBalance SRL commented (1). “This achievement reflects our dedication to developing innovative, science-backed probiotic ingredients. We also want to extend our gratitude to our Canadian partner Prebionature for their invaluable support throughout this journey. We are looking forward to seeing the first Canadian-licensed formulations in market in early 2025.”

Health Canada authorizes functional claim for SynbÆctive® Femme, a patented probiotic formula for women’s health 

https://microbiomepost.com/health-canada-authorizes-functional-claim-for-synbaective-femme-a-patented-probiotic-formula-for-womens-health/

A recent press release disclosed that Health Canada approved a functional claim authorization for SynbÆctive Femme, a patented probiotic formula used in women’s health.

Patented probiotic formula for women’s health, SynbÆctive Femme, receives functional claim authorization by Health Canada

NutriLeads BV (Wageningen, the Netherlands) has announced that it has entered into a sales and marketing agreement with Nexus Wise, expanding the global distribution of its precision prebiotic, Benicaros, to Malaysia. A prebiotic carrot fiber, the ingredient has been shown in research to support 

“We are excited to partner with Nexus Wise in Malaysia,” said Joana Carneiro-Wakefield, PhD, chief executive officer of NutriLeads, in a press release. “The company’s strong marketing and technical expertise will help manufacturers create innovative wellness solutions with Benicaros.”

“We are excited about our collaboration and eager to embark on this journey together,” added Chris Tan, chief executive officer and founder of Nexus Wise. “Benicaros is a truly unique product, and I believe that through our partnership, we have the potential to make a significant impact by incorporating Benicaros into innovative health solutions.”

NutriLeads has been rapidly growing the distribution of its ingredient. Most recently, NutriLeads signed a distribution agreement with LEHVOSS Group to distribute Benicaros in Europe, the Middle East, and Africa. The ingredient is also distributed in 

NutriLeads BV has announced that it has entered into a sales and marketing agreement with Nexus Wise.

NutriLeads expands distribution of its precision prebiotic ingredient to Malaysia

 Fall 2024 Industry Experts Symposium spotlights some of the natural product market’s biggest health targets, trends, and the ingredients designed to meet consumer and formulator needs. Don’t miss this deep dive on some of the market’s hottest ingredients.

https://www.nutritionaloutlook.com/no_w/industry-experts-2024


Looking for natural, proven solutions to support nutraceutical customers’ biggest health concerns? 

 Fall 2024 Industry Experts Symposium spotlights some of the natural product market’s biggest health targets, trends, and the ingredients designed to meet consumer and formulator needs. Listen to experts and company representatives discuss their latest leading condition-specific ingredients, and learn about what makes these ingredients promising, effective solutions for your next product.



Get an overview of what’s driving condition-specific nutraceutical markets

Learn about ingredients leaders in today’s nutraceutical categories

Get a detailed look at the science substantiating some of the industry’s leading condition-specific ingredients

 Thrive at Every Stage of Life: Exploring the Health Benefits of Setria® Glutathione

Katie Emerson, MS, RD/LDN, CISSN, Senior Manager, Scientific Affairs, Kyowa Hakko U.S.A, Inc.



From fighting oxidative stress to promoting healthy aging, glutathione is a powerful tripeptide found inside every human body. Setria® Glutathione is the versatile antioxidant built for your consumers: replenishing their primary defense system and supporting the detoxification process. Join us as we dive into how the world’s top-selling branded glutathione ingredient stands out from generic glutathione options.

10:30am PDT

Collagen Peptides in Nutricosmetics: Myth Busting

Lara Niemann, Global Marketing and Innovation, Category Management – Beauty, GELITA



Collagen peptides are among the hottest functional ingredients in the nutricosmetics market. This market, however, is flooded with misinformation that leaves both industry and consumers confused. Let's distinguish fact from fiction and discuss how VERISOL® Bioactive Collagen Peptides meet the needs of the most discriminating brand owners and consumers.

11:30am PDT

Capitalizing on the Healthy Longevity Shift: Innovations in Bone, Cardiovascular, and Sexual Health for Supplement Manufacturers



This webinar will highlight the emerging shift from healthy aging to healthy longevity, a trend poised to impact the supplement industry. Healthy longevity broadens the market opportunities as younger consumers look to extend performance and energy. Our expert will focus on the latest innovations in bone, cardiovascular, and sexual health.

12:30am PDT

 Live Q&A with Rafea Naffa, Scientific Advisor, AIDP

Optimizing Muscle Health in GLP-1 Users: The Role of HMB in Dietary Supplementation

Shawn Baier, MS, MBA, VP of Business Development, Innovative Ingredients, TSI Group



As GLP-1 receptor agonists gain popularity for managing weight and metabolic health, the potential impact on muscle mass and function has become a critical concern. This webinar will explore the synergistic role of HMB (β-Hydroxy β-Methylbutyrate) in counteracting muscle loss associated with GLP-1 use. Attendees will gain insights into the latest research supporting HMB's efficacy, its unique benefits as a muscle-preserving ingredient, and practical strategies for incorporating HMB into formulations tailored for individuals 

Webinar Date/Time: Thu, Sep 26, 2024 10:00 AM PDT (1:00 PM EDT)

Webcasts: Health Focus

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Nutritional Outlook’s Fall 2024 Industry Experts Symposium

 found that a novel keratin-based formulation called Keragen-IV from AIDP Inc. (City of Industry, CA) was able to support the skin and hair health in women. In the study, 65 women with healthy but stressed hair were assigned to either receive Keragen-IV or placebo for 60 days. Results showed that after 60 days, women taking the keratin-based formulation saw significant improvements in hair anchoring translating to a 43% reduction in hair loss. They also a 17.61% improvement in the birefringence of the hair cortex compared to placebo, suggesting that the active product increased the structural integrity of the hair cortex after 60 days.

When it came to skin health, participants taking Keragen-IV saw a significant 10% increase in gross skin elasticity after sixty days, compared to placebo. They also saw improvements in skin barrier function as measured by 12.5% lower levels of trans epidermal water loss after 30 days, compared to baseline. However, compared to placebo, this improvement was not statistically significant. Previous 

 have demonstrated that Keragen-IV works by increasing the expression of collagen IV. According to the researchers, “ The known function of collagen IV as a junctional protein is to build skin structure at the dermal-epidermal junction and further to bind hair follicles as the anchoring protein at the hair root, keeping hair well anchored to the head.”

One of the study's principal researchers, Jennifer Gu, PhD, vice president of research and development at AIDP, Inc. said in a press release “This study verifies Keragen-IV®’s role in hair anchoring which is a concern for many women experiencing hair loss due to hormonal changes or stress. It also indicated Keragen-IV®’s role in skin elasticity which can deteriorate as one ages.”

Kelly, R.; Gu, J.; Lim, J.; Lati, E.; Manna, V. Effect of keraGEN IV Keratin oral supplementation on hair, skin, and nail attributes. 

Tang, L.; Sierra, J.O.; Kelly, R.; Kirsner, R.S.; Li, Jie. Wool-derived keratin stimulates human keratinocyte migration and types IV and VII collagen expression. 

Updated on September 24, 2024 at 8:52AM Eastern

A recently published study found that a novel keratin-based formulation called Keragen-IV from AIDP Inc. was able to support the skin and hair health in women.

Brian Cornblatt, PhD

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