Recent study finds that Solnul resistant potato starch may support histamine resistance and intestinal permeability

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MSP Starch Products Inc. (MSP; Carberry, MB, Canada) has announced the results of new metabolomic research highlighting the impact of its resistant potato starch (marketed as Solnul) on histamine sensitivity and intestinal permeability, known as leaky gut. Researchers performed a post hoc exploratory metabolomic analysis of serum amino acid, amine, and carnitine metabolites in subjects consuming 3.5 g/day of resistant potato starch or placebo. They used liquid chromatography mass spectrometry to determine if the starch positively influenced histamine metabolism and related parameters.

Results showed that the resistant potato starch significantly reduced histamine levels, but histamine-degrading enzyme products were not affected. Additionally, researchers observed that histamine-secreting Haemophilus and Lactobacillus were also reduced following consumption of the resistant potato starch. When it comes to intestinal permeability, the starch significantly reduced 5-hydroxylysine, acetylspermidine, and short- and medium-chain carnitines ratios, which are metabolites associated with intestinal permeability. According to the researchers, this suggests that a decrease in serum histamine may be related to enhanced gut barrier function.

"Histamine sensitivity was thought to be due to our bodies' inability to break down histamine and stop the inflammatory response. Our findings connect changes in histamine to reductions in histamine-producing bacteria and improvements in gut barrier function via Solnul supplementation using a combination of microbiome and metabolomic data," explained Jason Bush, PhD, chief scientific officer at MSP, in a press release.

"This type of research is particularly exciting for us as few companies are using metabolomics to substantiate claims for their ingredients" added Jason Leibert, chief growth officer at MSP "These cutting-edge structure/function claims will give our commercial partners a competitive advantage and support the health goals consumers are seeking."

Reference

Bush, J.R.; Han, J.; Deehan, E.C.; Harding S.V.; Maiya, M.; Baisely, J.; Schibli, D.; Goodlett, D.R. Resistant Potato Starch Supplementation Reduces Serum Histamine Levels in Healthy Adults with Links to Attenuated Intestinal Permeability. Journal of Functional Foods, 2023, Article ASAP. DOI: https://doi.org/10.1016/j.jff.2023.105740 (accessed 2023-8-29)