ATP Supplementation Prevents Post-Exercise Drop in ATP, Study Suggests


Researchers also found that the Peak ATP ingredient from TSI enhanced peak power and muscle excitability.

Photo © Rao

Photo © Rao

There’s now one more piece of research supporting the exercise-recovery potential of ATP (adenosine-5’-triphosphate), as TSI USA Inc. (Missoula, MT) has announced promising new study results supporting its Peak ATP ingredient. Writing in the Journal of the American College of Nutrition, researchers found that ATP supplementation prevents exercise-induced declines in ATP levels, and enhances peak power and muscular excitability, also known as the ratio of power output to muscle activation.

The double-blind, placebo-controlled study included 42 healthy men aged 18–30 who were randomized to consume either 400 mg of Peak ATP or a placebo for two weeks. At the end of the supplementation period, subjects participated in an intense exercise bout that consisted of high-intensity sprinting. Researchers measured muscle activation and excitability during the exercise bout, as well as peak power with the Wingate test. ATP and related metabolites were also measured at baseline, at the end of the two-week supplementation period, and immediately following the exercise.

Researchers found that ATP supplementation appeared to prevent post-exercise drops in ATP, adenosine-5’-diphosophate (ADP), and adenosine-5’-monophosphate (AMP). No effect was found on muscle activation, but ATP supplementation was also found to significantly increase Wingate peak power in later exercise bouts compared to baseline. What’s more, while the placebo group showed a significant decrease to muscle excitability in later exercise bouts, no such decline was observed in the ATP group.

“Oral ATP administration prevents exercise-induced declines in ATP and its metabolite, and enhances peak power and muscular excitability, which may be beneficial for sports requiring repeated high-intensity sprinting bouts,” researchers concluded.

TSI USA, in its study announcement, notes that the new study builds upon other research finding Peak ATP may help reduce post-workout muscle fatigue.

“Peak ATP is the only ingredient we know of that is proven to boost muscular excitability, a new and exciting category in sports nutrition,” says Larry Kolb, president of TSI USA. “By boosting muscular excitability, Peak ATP provides a critical advantage to athletes who want to increase the intensity and/or frequency of their workouts, and ultimately see better results from their efforts. Instead of fatiguing, athletes are able to push themselves harder because they are able to maintain muscle contractions during high-intensity workouts.”


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Michael Crane
Associate Editor
Nutritional Outlook Magazine


Purpura M et al., “Oral adenosine-5’-triphosphate (ATP) administration increases postexercise ATP levels, muscle excitability, and athletic performance following a repeated sprint bout,” Journal of the American College of Nutrition. Published online January 12, 2017.

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