Zeaxanthin Shows Anti-Tumor Potential in Skin Cancer

September 1, 2010

Wu NL et al., “Zeaxanthin inhibits PDGF-BB-induced migration in human dermal fibroblasts,”

Wu NL et al., “Zeaxanthin inhibits PDGF-BB-induced migration in human dermal fibroblasts,” Experimental Dermatology, vol. 19, no. 8 (August 2010): e173-e181.

Researchers in Taiwan have concluded that zeaxanthin-a carotenoid found naturally in marigolds, some leafy greens, and other foods-may have anti-tumor potential in cases of melanoma.

After previously conducting research on green tea and lycopene’s interactions with melanoma skin cells, the same team of researchers sought to test the effects of zeaxanthin interacting with melanoma skin cells, in vitro. Using a Boyden chamber system and electric cell-substrate impedance sensing (ECIS) to examine human fibroblast and melanoma skin cell migrations, the researchers determined that zeaxanthin inhibited the migration of human fibroblasts induced by platelet-derived growth factor (PDGF) and melanoma cells.

“The findings and concepts disclosed here will promote further exploration of more functions and molecular mechanisms of zeaxanthin and also support the therapeutic potential of zeaxanthin in the treatment of melanoma,” wrote the study’s authors.