In cell cultures, the pomegranate extract was shown to modulate collagen and hyaluronic acid metabolism.
A recent study1 evaluated the effects of a proprietary pomegranate extract (Pomanox from Euromed, based in Mollet del Vallès, Spain) on skin health-related parameters in normal and UV-induced photoaging conditions in human fibroblast Hs68 cells. Ultraviolet radiation can degrade the skin’s extracellular matrix components leading to hyperpigmentation and loss of skin elasticity.
Researchers used both preventative and regenerative assays in which Hs68 cells were exposed to UV radiation after treatment (preventative) with the pomegranate extract or prior to treatment (regenerative). Results showed that in normal conditions, the pomegranate extract significantly modulated collagen and hyaluronic acid metabolism, and in UV-exposed cells positively modulated hyaluronic acid metabolism and decreased reactive oxygen species (ROS) in both preventative and regenerative treatments.
Only the preventative treatment, however, modulated collagen metabolism when exposed to UV radiation. Additionally, the pomegranate extract demonstrated a marked inhibitory capacity of tyrosinase activity, which is a melanogenic enzyme responsible for production of melanin through oxidation of tyrosine substrates in the melanogenesis process.
Mariné-Casadó R, Teichenné J, Tobajas Y et al. Pomegranate natural extract Pomanox® positively modulates skin health-related parameters in normal and UV-induced photoaging conditions in Hs68 human fibroblast cells. International Journal of Food Sciences and Nutrition. 2022: https://doi.org/10.1080/09637486.2022.2152189