Subjects taking the polyphenol-rich extract saw greater improvements in cognitive function compared to placebo, but these differences were not statistically significant. The study does justify further research to investigate the extract's benefits at low doses.
A recent study1 found that a polyphenol-rich grape and blueberry extract called Memophenol, from Activ’Inside (Bordeaux, France), may support cognitive health in subjects with mild cognitive impairment. In the randomized, double-blind, placebo-controlled study with two arms and parallel groups, 143 subjects between the ages of 60 and 80 with mild cognitive impairment were given either 150 mg of the extract or placebo twice daily for six months.
To measure cognitive function, including episodic memory, working memory, accuracy of attention, speed of information processing, and visuospatial learning, researchers used The Computerized Mental Performance Assessment System (COMPASS) the Behavior Rating Inventory of Executive Function (BRIEF-A), the Cognitive Failures Questionnaire, and the CASP (Control, autonomy, self-realization, and pleasure)-19. Results showed that compared to placebo, subjects taking the polyphenol-rich extract saw greater improvements in speed of information processing, visuospatial learning, and BRIEF-A global score, however, the differences did not reach statistical significance.
According to Activ’Inside, previous research showed that the polyphenol-rich extract was beneficial for cognitive health at doses of 600 mg per day. The current research, while not statistically significant, shows the promise of the ingredient at smaller doses and the need for further research to validate and expand upon its findings, said the researchers.