Natural antioxidant Neumentix supports inflammation and cognitive performance in preclinical study

November 12, 2020
Sebastian Krawiec

The results of the study, published in two peer-reviewed journals, found improved cognitive and motor performance, as well as reduced expression of oxidative stress and inflammation.

A results of a recent animal study have been published in the Journal of Stroke and Cerebrovascular Diseasesand Current Neurovascular Research. In the study, mice were pretreated with a vehicle or 134 mg/kg/d of Neumentix for 14 days. Neumentix (Kemin Industries; Des Moines,IA) is natural, patented spearmint extract rich in polyphenols, including high concentrations of rosmarinic acid, as well as salvianolic, lithospermic, and caftaric acids.

Results showed that Neumentix helped improve cognitive and motor performance of mice following a mid-brain ischemic stroke, and animals treated with the extract before and after the procedure scored better in a sensory motor functional assessment and presented less motor impairment than untreated animals. Following brain tissue analysis, researchers found that supplementation with Neumentix may have protected neurons by reducing the expression of markers of oxidative stress (4-HNE, CML, 8-OHdG) and inflammation (Iba-1, MCP-1, TNF-a). These markers are known to over-express following a stroke and may worsen brain damage.

“The present study provides evidence of Neumentix’s anti-inflammatory and neuroprotective properties,” said Koji Abe, MD, PhD, professor and chairman of Neurology at Okayama University Medical School in Japan and the study’s lead researcher, in a press release. “This research further illuminates the mechanisms by which Neumentix supports brain health and cognitive function.”

“This important new research provides further evidence of the antioxidant strength of Neumentix, which protects neurons and gets to the right areas of the brain to enhance the ability to focus and support short-term memory and physical agility,” added Kim Edwards, global product manager, Kemin Human Nutrition and Health, in a press release. “These multiple health benefits can differentiate products and enable a wide range of science-based marketing claims.”

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