Hyaluronic acid matrix from Bioiberica may support oxidative stress, signs of aging, and skin health, according to recent study


A recent in vitro study found that a proprietary hyaluronic acid (HA) matrix from Bioiberica, called Dermial, may show offer antioxidant, regenerative and anti-aging benefits.

Photo © Shutterstock.com/goodluz

Photo © Shutterstock.com/goodluz

A recent in vitro study published in the International Journal of Molecular Sciences found that a proprietary hyaluronic acid (HA) matrix from Bioiberica (Barcelona, Spain), called Dermial, may show offer antioxidant, regenerative and anti-aging benefits. The ingredient, isolated and purified from rooster comb was evaluated and determined to be composed of 67% hyaluronic acid, a high concentration, as well as 10% sulphated Glycosaminoglycans (GAGs), and 17% protein, including 10.4% collagen. GAGs, such as HA, are an important component of the extracellular matrix found in the skin, maintaining hydration, and regulating cell migration, proliferation, and differentiation. In vitro evaluation found that the HA matrix stimulated the migration and proliferation of human dermal fibroblast (HDF) and human epidermal keratoinocytes (HEK). “These cellular properties improve the rate of cell replenishment, providing a regenerating effect on the epidermis and dermis,” the researchers write.

The HA matrix was also shown to reduce oxidative stress, which is major contributor of skin aging because excess accumulation of reactive oxygen species (ROS) can cause DNA damage and induce the skin’s inflammatory response, which reduces antioxidant enzymes, inhibits collagen production and increases metalloproteinases (MMP), leading to the degradation of extracellular matrix (ECM) elements in the dermis. The researchers found that the HA matrix demonstrated an antioxidant effect on HDF and HEK, with a more pronounced effect on HEK. Finally, the HA matrix was found to also induce cell proliferation and migration, increasing the synthesis of collagen I and II, elastin, and GAGs. All these results suggest anti-aging properties based on the ingredients impact on cellular and molecular mechanisms, as well as the potential to improve skin conditions such as hydration, elasticity, firmness, and dermal density.

“The conclusions of this latest peer-reviewed paper mark an exciting development in the research exploring Dermial – further verifying the science-based benefits of the ingredient and its potential in nutricosmetics,” said Daniel Martínez Puig, head of human health R&D for Bioiberica, in a press release. “We can’t wait to unlock exciting opportunities for brands already in or considering entering this market. Following these promising outcomes, our next step will be to carry out a clinical trial to confirm the efficacy of Dermial® in humans.”

“The ‘beauty-from-within’ market has witnessed rapid growth in recent years, fueled by rising consumer interest in overall wellbeing, the holistic health movement and growing awareness that beauty can be achieved from the inside-out via nutrition,” added Antonio Vendrell, Bioiberica’s marketing director. “Many consumers are taking a more proactive approach to their skin health, making them more open to trying nutritional solutions – including ingestible beauty products. This has created a new space for novel ingredients like Dermial.”


Galvez-Martin, P.; Soto-Fernandez, C.; Romero-Rueda, J.; Cabañas, J.; Torrent, A.; Castells, G.; Martinex-Puig, D. A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity. Int. J. Mol. Sci. 2023, 24(5): 4774. DOI: 10.3390/ijms24054774

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