Citrus and pomegranate complex supports physical fitness and mental wellbeing of elderly subjects in recent study


Subjects showed improvements in hand grip strength tests as well as thinking, learning, memory, and concentration parameters of the psychological function domain of quality of life survey.

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A recent study published in the Journal of Nutrition, Health & Aging1 investigated the effects of a citrus and pomegranate complex (Actiful from BioActor BV, based in Maastricht, The Netherlands) on the physical fitness and mental well-being of healthy elderly subjects between the ages of 60 and 75. In the randomized, placebo-controlled cross-over trial, 36 subjects were either given the complex (two 350 mg gelatin capsules) or placebo daily for four weeks. After a four-week washout period, the intervention was switched for each subject for another four weeks. Subjects performed a handgrip strength test and senior fitness test, as well as a Quality of Life (WHO-QOL-100) questionnaire and gave blood samples before the start and upon completing each four week intervention period.

Results showed a significant improvement in hand grip strength compared to placebo, as well as a time treatment interaction on the psychological function domain of the WHO-QOL-100 questionnaire. Researchers investigating the five facets that make up psychological function separately, which include: positive feelings; thinking, learning, memory, and concentration; self-esteem; bodily image and appearance; and negative feelings. Results showed that supplementation resulted in a significant time treatment effect for thinking, learning, memory, and concentration, compared to placebo. Blood samples also showed significant reductions in malondialdehyde (MDA), a biomarker of oxidative stress, compared to placebo.


  1. Ahles S. et al. “The effect of a citrus and pomegranate Ccomplex on physical fitness and mental well-being in healthy elderly: A randomized placebo-controlled trial.” Journal of Nutrition, Health & Aging, vol. 26 (2022); 839-846,
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