Antioxidant research update: Polyphenols, resveratrol, lycopene, lutein, and tocotrienols

June 12, 2019

Photo © jucha

The antioxidant market is rapidly growing, and this growth is driving important changes in the way antioxidant ingredients are formulated and marketed. Lower manufacturing costs and higher consumer demand for natural products are expected to ultimately drive the global antioxidant supplement market to a USD $4.5 billion valuation by 2022, up from USD $2.9 billion in 2015, per Allied Market Research.1

As this market growth opens up new opportunities for antioxidant brands and manufacturers, expect consumer needs and ingredient research to influence how brands will successfully develop and market antioxidant supplements. Here are just some of the ways that the antioxidant market—and antioxidants themselves—are evolving.


  1. Prasad E. “Antioxidants market by type, natural (Vitamin A, Vitamin B, Vitamin C, and Rosemary Extract), synthetic (butylated hydroxyanisole, butylated hydroxytoluene, and others) – Global opportunity analysis and industry forecast, 2014-2022.” Allied Market Research. Published online December 2016.
  2. Polley KR et al. “Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity.” Applied Physiology, Nutrition, and Metabolism, vol. 41, no. 1 (January 2016): 26-32
  3. Groten K et al. “Tomato phytonutrients balance UV response: results from a double-blind, randomized, placebo-controlled study.” Skin Pharmacology and Physiology, vol. 32, no. 2 (March 2019): 101–108
  4. Renzi-Hammond LM et al. “Effects of a lutein and zeaxanthin intervention on cognitive function: A randomized, double-masked, placebo-controlled trial of younger healthy adults.” Nutrients, vol. 9, no. 11 (November 2017): 1246-1258
  5. Shen CL et al. “Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: A 12-week randomized double-blind placebo-controlled trial.” Osteoporosis International, vol. 29, no. 4 (April 2018): 881-891
  6. Starling S. “Veteran researcher: Polyphenols don’t work as antioxidants in vivo, but…” Published online July 11, 2010.
  7. “Fytexia launches a new grade of Oxxynea supplying clinically proven bioavailability and demonstrated efficacy in counteracting oxidative-stress in vivo.” Fytexia website. Published online October 18, 2018
  8. Obayashi S. “Electron accelerators reveal the radical secrets of antioxidants.” EurekAlert/American Association for the Advancement of Science. Published online March 19, 2019.