Improved Adiponectin:Leptin Ratios
Previous research has found that curcumin offers benefits to those experiencing insulin resistance. Yunes Panahi and colleagues from Baqiyatallah University of Medical Sciences (Tehran, Iran) investigated in a 2016 study whether this beneficial effect occurred through curcumin’s interactions with the adipokines adiponectin and leptin.4 Adiponectin is known to mediate an insulin-sensitizing effect while leptin is a hormone that is known to be increased in obesity, but whose ultimate net effect is to inhibit appetite, stimulate thermogenesis, enhance fatty acid oxidation, decrease glucose, and reduce body fat in the obese state.5 Improving the ratio of adiponectin to leptin is thought to support healthy insulin function.
In the randomized, placebo-controlled trial, individuals with metabolic syndrome were asked to supplement with curcumin (1,000 mg/ day) or a placebo for eight weeks. Serum levels of adiponectin and leptin were measured before and after the intervention. Curcumin treatment was associated with a significant increase in serum adiponectin and a reduction of serum leptin levels, a potential mechanism for curcumin’s ability to support healthy insulin sensitivity.
4. Panahi Y, et al., “Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial,” Nutrition, vol. 32, no. 10 (October 2016):1116-1122
5. Yadav A, et al., “Role of leptin and adiponectin in insulin resistance.” Clinica Chimica Acta, vol. 417 (February 18 2013): 80-84
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