Polysaccharides from Agaricus bisporus support weight and cholesterol, says recent study

March 20, 2020

A study recently published in the American Journal of Biomedical Science and Research found that proprietary water-soluble polysaccharides from Agaricus bisporus (H2Oslim by Nutraceuticals Group; Bloomingdale, NJ) may reduce body weight and support lipid parameters. In the randomized, double-blind, placebo-controlled study 100 healthy overweight volunteers were given either 400 mg per day of H2Oslim or placebo for 12 weeks, and evaluated at baseline, 4, 8, and 12 weeks.

Results showed that subjects taking H2Oslim experienced significant reductions in body weight, waist circumference, plasma total cholesterol, and LDL cholesterol, compared to placebo. Both groups showed similar food intake habits and energy levels. Changes in weight and waist circumference showed significance compared to placebo at week 4 to week 12, with lipid parameters showing significance at week 12. Based on the results, the researchers conclude that polysaccharides from the common mushroom Agaricus bisporus are an efficacious, allergen-free, and water-soluble alternative to chitosan.


1. Clemente-Ramos G et al. “H2Oslim, the water-soluble polysaccharides from Agaricus bisporus, significantly reduces body weight and improves lipid parameters in overweight humans in a randomized double-blind vs placebo study.” American Journal of Biomedical Science and Research, vol. 7, no. 6 (2020): 479-482