Patented Bitter Orange Extract Suppresses Appetite in New Study

September 1, 2017

A study recently published in Nutrition and Dietary Supplements1 indicates that a patented bitter orange extract (Citrus aurantium) and its primary protoalkaloid p-synephrine, as branded thermogenic ingredient Advantra Z from Novel Ingredient Services (East Hanover, NJ), may help suppress appetite and reduce food intake. The study found that, in addition to increasing appetite control, Advantra Z also increased subjects’ energy levels. According to Novel Ingredient Services, this study is the first to focus on Advantra Z’s efficacy in appetite suppression and food intake.

The placebo-controlled, double-blinded study was conducted with 40 overweight adults. Subjects were instructed to consume one chocolate-flavored chew containing either a placebo or 100 mg of bitter orange extract standardized to 51.5 mg of p-synephrine as Advantra Z, before two of their largest meals each day for a period of 30 days. In addition, subjects were asked to complete a questionnaire each day rating eating control, energy level, and palatability.

After a head-to-head comparison of the active product and placebo group’s questionnaires, researchers found that subjects given Advantra Z chews reported significantly higher positive scores for appetite control and energy levels, compared with the placebo group. Further, no adverse events were reported throughout the course of the study.

The researchers noted that the results were consistent with previous studies demonstrating Advantra Z’s safety and efficacy. Novel Ingredient Services adds that more than 30 research studies support the ingredient’s safety and efficacy. The company says that Advantra Z contains only natural p-synephrine, which is a stable synephrine isomer, and does not contain any m-synephrine, an isomer that can increase blood pressure and heart rate in humans.

  1. Kaats GR et al., “Increased eating control and energy levels associated with consumption of bitter orange (p-synephrine) extract: a randomized placebo-controlled study,” Nutrition and Dietary Supplements, vol. 9 (2017): 29-35