BIOHM, a novel probiotic formulation, fights a new foe called digestive plaque, SupplySide West 2019 report

November 5, 2019

BIOHM is the newest ingredient in AIDP Inc.'s (City of Industry, CA) digestive health portfolio. A novel approach to supporting digestive health, BIOHM is a probiotic formula that combines good bacteria (Bifidobacterium breve, Lactobacillus acidophilus, Lactobacillus rhamnosus) and good fungi (Saccharomyces boulardii), with the enzyme amylase to break down digestive plaque and recondition the gut. Digestive plaque, also known as digestive biofilm, is a thick layer of organisms that form along the lining of the gut, protecting bad bacteria and fungi. Digestive plaque is very difficult to break down and can even be resistant to antibiotics. Similar to plaque found on teeth that cause gum disease, oral plaque protects the germs underneath, which continue to spread. The germs cannot be stopped unless the plaque is broken down.

In an in vitro study published in Therapeutics and Prevention1, BIOHM was shown to prevent the formation of digestive plaque as well as significantly reduce the thickness of digestive plaque. The formula was devised by Mahmoud Ghannoum, PhD, MBA, FIDSA, Director of the Center for Medical Mycology at Case Western Reserve University and University Hospitals Cleveland Medical Center. Ghannoum chose components that would work synergistically in order to break down plaque, control the exposed bad bacteria and fungus, and then continue to inhibit the formation of plaque.

According to the authors of the study in Therapeutics and Prevention, amylase has been shown to inhibit the growth of digestive plaque, and S. boulardii has been shown in research to secrete fatty acids and 2-phenylethanol, including capric acid, a compound shown to be “most effective in inhibiting candidal pathogenicity determinants, including the yeast-to-hyphal morphological transition, adhesion, and biofilm formation.” They also write that “metabolites secreted by S. boulardii may contribute to the ability of our probiotic to interfere with the virulence factors of these pathogens.”

With regard to the probiotics, say the researchers, “Metabolites released by Lactobacillus species, such as sodium butyrate, have been shown to inhibit biofilm formation, to potentiate the effect of antifungal agents…thereby reducing fungal pathogenicity.” The production of lactic acid and other organic acids by Lactobacillus spp. also significantly decreases the pH in the gut, which is an important factor in fungal growth.

The health implications of the formula are significant because digestive plaque has been recognized as a primary contributor to host infections and gastrointestinal diseases such as Crohn’s disease.


1. Hager CL et al. “Effects of a novel probiotic combination on pathogenic bacterial-fungal polymicrobial biofilms.” Therapeutics and Prevention, vol. 10, no. 2 (2019)