Polyphenol-rich extract received authorized health claim in South Korea

February 11, 2020

The South Korean Ministry of Food and Drug Safety has recognized the effects of Memophenol (from Activ’Inside; Beychac & Caillau, France) on cognitive performance, specifically memory, with an authorized health claim. A number of recent studies have validated the patented formulation of grape and blueberry polyphenols for the support of memory across various age groups.

In a study published in the Journals of Gerontology1, 215 healthy volunteers between the ages of 60 and 70 were randomized to receive either 600 mg of Memophenol per day or placebo for six months. Results showed that supplementation significantly improved verbal episodic and recognition memory (VRM) free recall as well as VRM-delayed recognition, demonstrating that the ingredient may help improve age-related episodic memory decline.

In another study published in Antioxidants2, 30 healthy university students between the ages of 18 and 25 were randomized to receive a single dose of 600 mg of Memophenol or placebo. Ninety minutes after consumption, the subjects’ cognitive function was assessed for an hour. Results showed that supplementation supported working memory and attention, specifically producing a 2.5-fold increase in serial three subtraction variation net scores, compared to placebo.

"This is a positive conclusion to several years of clinical research and it proves the efficacy of Memophenol on memory," said Benoit Lemaire, CEO and business and marketing vice president of Activ’Inside, in a press release. "We are confident that this positive scientific opinion will allow wider applications of our ingredient in health supplements as we believe cognitive performance is and will remain a major concern worldwide."


1. Bensalem J et al. “Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study.” Journals of Gerontology, vol. 74, no. 7 (2019): 996-1007

2. Philip P et al. “Acute intake of a grape and blueberry polyphenol-rich extract ameliorates cognitive performance in healthy young adults during a sustained cognitive effort.” Antioxidants, vol. 8, no. 12 (2019): 650