SupplySide West
Features
GMP Compliance, Booth 13019
Vitamin K Study, Booth 20025
CGMP Compliant Manufacturing, Booth 14042
New Products
Solid Dosage Test Equipment, Booth 10004
Pearlescent Liquid Capsules, Booth 16018
Freeze-Dried Kiwi, Booth 10013
Deodorized DHA, Booth 20049
Loquat Leaf Extract, Booth 19043
Probiotic Yeast/Bacteria Combination, Booth 20005
Presentations & Seminars
Joint Committee Meeting
Tuesday, Nov. 6th 1:00 to 5:00 pm Lido Ballroom
UCII Osteoarthritis Human Clinical Trial
Tuesday, Nov. 6th 1:00 to 1:50 pm Room 18071
Cosmeceuticals and Dietary Supplements
Tuesday, Nov. 6th 4:00 to 4:50 pm Lido Room 3001-3002
HMRlignan and Women's Health
Tuesday, Nov. 6, 3:00 P.M., Lido Room 3101-3102, Level 3
In its 10th year, SupplySide West has become the preeminent marketplace for the natural products industry. More than 1000 suppliers will be on hand from November 7-8 ,when the show takes place at the Venetian & Sands Exposition Center in Las Vegas. The following companies provided information about their SupplySide West activities and products.
Nutritional Laboratories International (NLI) will discuss meeting the new good manufacturing practices issued by FDA. Large companies face a 2008 compliance deadline. NLI has available capacity in capsule, tablet, and packaging processes, and understands the requirements needed to assist you in becoming fully compliant.
Over the past several months, NLI has been actively expanding and refining its quality manufacturing services and processes, including the following key areas:
- NSF certification for good manufacturing practices
- Certified-organic handling for the processing of dietary supplements
- Six Sigma Lean manufacturing and process improvement systems
"NLI continues to push the quality level of dietary supplements to the highest level possible by following strict manufacturing guidelines, to ensure the products we manufacture meet current and future customer demands," stated NLI President and CEO Mike Zeher.
NLI welcomes international visitors to the booth to discuss how it can support products that require documentation support and offer superior-quality products for markets around the world. NLI also offers a line of stock formulas—both basic and premium—to help a company quickly expand its portfolio of quality products and product-registration efforts. For more information, contact Nutritional Laboratories International (Missoula, MT) by visiting www.nutritionallabs.com or calling 406/273-5493.
A new study published online in the journal Laboratory Investigation suggests vitamin K plays a vital role in skin and soft-tissue health. According to PL Thomas (Morristown, NJ), the study links a vitamin K-dependent protein called matrix GLA protein (MGP) to increased mineralization of elastic fibers in the skin of patients with pseudoxanthoma elasticum (PXE), a population subject to severe calcification. These results may also illustrate the need for active MGP in healthy populations with subclinical vitamin K deficiency.
PXE is a progressive disorder that is characterized by accumulated deposits of calcium (calcification) and other minerals in elastic fibers, which are a component of connective tissue. Calcification can affect elastic fibers in the skin, eyes, and blood vessels, causing decreased blood flow.
Matrix GLA protein (MGP) is the most potent inhibitor of soft-tissue calcification known, and it was found that blood levels of MGP in patients with PXE were dramatically lower than normal patients.
According to Leon Schurgers, PhD, one of the authors of the paper, "This patient population provides insight to the role of MGP and calcification—and we hope to apply this knowledge toward therapeutic applications for these patients. In healthy populations with vitamin K deficiency, and thus susceptible for high levels of inactive MGP, excess calcification can become a real health concern, particularly in regard to calcification of the arteries. Unfortunately, the Western diet is likely deficient in adequate vitamin K for these needs."
The study also examined active vs. inactive MGP content in the skin of PXE patients compared to control patients. Normal elastic fibers in control patients had more abundant active MGP compared to PXE patients. Also, in the PXE patients' calcified elastic fibers, inactive MGP intensively accumulated with mineral deposits. Finally, examination of cell cultures showed PXE patients produced 30% less active MGP than control patients. These findings demonstrate MGP's involvement in elastic fiber calcification.
Schurgers also commented on the need for dietary vitamin K. "Recognizing the need for additional vitamin K in our diets led our group at VitaK at the University of Maastricht to evaluate the different supplemental sources of vitamin K, including vitamin K1 and vitamin K2 as menaquinone-4 and as menaquinone-7 (MK-7). Due to its good bioactivity in the body, and long half-life in the blood, MK-7 is the obvious choice for enrichment of dietary supplements and functional foods."
The benefits of vitamin K for cardiovascular health are tied to its role activating MGP, the most potent inhibitor of vascular calcification known. This role gained attention by the findings of a study published in the Journal of Nutrition called the "Rotterdam Study" in 2004, involving over 4800 people over a ten-year period. The study found increased intake of specifically natural vitamin K2 significantly reduced the risk of CHD mortality by 50%, compared to low dietary vitamin K2 intake. In this study, vitamin K1 had no effect at all. For more information, contact PL Thomas (Morristown, NJ) by visiting www.plthomas.com or calling 973/984-0900.
CGMP-Compliant Custom Manufacturing
Booth 14042
Vita-Tech International Inc. (Tustin, CA), a United States-based custom manufacturer and innovator of nutritional supplements, offers both CGMP compliance and advanced pharmaceutical technology to its clients.
"Anticipating recent changes in CGMP compliance, we have stayed well ahead of industry regulation with our focus on continuous improvement in manufacturing standards and quality assurance," commented Vita-Tech CEO Thomas T. Tierney. "We continue to invest in the latest advances in technology and equipment for many reasons-compliance, of course, as well as a net savings of time and money for clients."
"Also," Tierney noted, "Vita-Tech's pharmaceutical manufacturing environment has been licensed by FDA for its entire 53 years of service to the natural products industry worldwide."
Vita-Tech uses technology to streamline process validation, as well as raw-material testing, documentation, and sampling. Using high-capacity, high-speed equipment, Vita-Tech achieves efficiency in lot control, batch-number tracking, and raw-material sampling and retention.
The company manufactures tablets, two-piece capsules, powders, and powdered drinks of the highest quality and offers a modern analytical laboratory, formulation design, flavor expertise, packaging services, and rigorous quality assurance. In addition, Vita-Tech offers two-piece capsule, banding capabilities. Vita-Tech serves contract manufacturers and private-label clients globally. No job is too large or too complex. Vita-Tech has the ability to manufacture to the most stringent international requirements and to respond to short lead times. For more information, contact Vita-Tech by visiting www.vitatech.com
New Products
Solid-Dosage Test Equipment
Booth 10004
Dr. Schleuniger Pharmatron (Manchester, NH) will exhibit its full range of solid-dosage test equipment. The company offers a broad product range, including fully automatic, semiautomatic, and manual models for quality control and in-line production testing of tablets and capsules. Prominent among these are tablet-testing machines for weight, thickness, diameter, and hardness as well as disintegration and abrasion. For more information, contact Dr. Schleuniger Pharmatron by visiting www.pharmatron.com or calling 800/641-6766.
Pearlescent Liquid Capsules
Booth 16018
Pearlescent liquid capsules provide dietary supplement manufacturers a wide array of color options. The tinted Licaps capsules contain Candurin, a light-reflecting pigment composed of mica and titanium dioxide. When used alone, Candurin creates a pearl-white color; when used with other dyes, it can create a palette of colors, such as pink, green, turquoise, purple, powder blue, orange, charcoal, bronze, silver, and gold. For more information, contact Capsugel (Greenwood, SC) by visiting www.capsugel.com or calling 864/942-3063.
Fruits that are freeze dried lack moisture but retain their original flavor, color, and cell structure. Kiwi fruit is high in vitamin C and is a good source of fiber, vitamin E, and potassium. Freeze-dried kiwi is shelf stable and available in powder form, multiple-dice slices, or half-slice cuts for use in cereals, salad dressings, dry blends, teas, trail and snack mixes, and desserts. For more information, contact Van Drunen Farms (Momence, IL) by visiting www.vandrunenfarms.com or calling 815/472-3100.
A new omega-3 acid ingredient is nanoencapsulated, deodorized, and water soluble, making it a useful choice for food, beverage, and nutritional supplement applications. Derived from fish, VitaDHA contains docosahexaenoic acid in either liquid or powdered form. For more information, contact Blue California (Rancho Santa Margarita, CA) by visiting www.bluecal-ingredients.com or calling 949/635-1990.
Loquat Leaf Extract
Booth 19043
A botanical ingredient extracted from the loquat tree (Eriobotrya japonica) contains corosolic acid, which may help enhance glucose metabolism. The ingredient is extracted using ethanol via patent-pending technology developed by Tokiwa Phytochemical Co. (Tokyo). For more information, contact OptiPure Brand Chemco Industries (Los Angeles) by visiting www.optipure.com or calling 323/726-0700.
Probiotic Yeast/Bacteria Combination
Booth 20005
A new probiotic formulation developed for intestinal disorders combines probiotic yeast and bacteria, Protecflor contains Saccharomyces boulardii probiotic yeast with three specific probiotic bacteria strains: Lactobacillus Rosell-11, Lactobacillus Rosell-52, and Bifidobacterium Rosell-175. S. boulardii are said to eliminate certain pathogens and C. difficile toxins A and B. S. boulardii has the ability to bind to E. coli pathogens, forming easily eliminated large agglutinates. Lactobacillus Rosell-11 and Lactobacillus Rosell-52 probiotic bacteria have the ability to adhere to the gut surface. By reinforcing the intestinal barrier, they prevent the adhesion and colonization of the gut by pathogens, thereby constituting an effective second line of defense. For more information, contact Institut Rosell-Lallemand (Montreal) by visiting www.institut-rosell.com or calling 514/381-5631.
Presentations and Seminars
Joint Committee Meeting
Tuesday, Nov. 6, 1:00 P.M. to 5:00 P.M., Lido Ballroom
NSF will sponsor a Joint Committee Meeting of its clients and stakeholders to discuss the pending GMPs and NSF's certification program. To reserve a seat, contact Sarah Kozanecki at 734/827-6867 or kozanecki@nsf.org. One attendee will be selected for a complimentary NSF GMP registration. Stop by Booth 25043 to enter to win, or look inside the SupplySide West show bag given out at registration for an entry form.
In today's rapidly growing dietary supplements industry, manufacturers can now differentiate their products through the NSF International third-party product-certification services, which include product certification and facility GMP registration. Visit NSF at SupplySide West to understand how NSF's product certification and GMP registration can differentiate your business in the marketplace. For more information, contact NSF (Ann Arbor, MI) by visiting www.nsf.org or calling 734/769-8010.
UCII Osteoarthritis Human Clinical Trial
Tuesday, Nov. 6, 1:00 P.M. to 1:50 P.M., Room 18071
Debasis Bagchi, professor at Creighton University Medical Center (Omaha, NE) and senior vice president of research and development for Interhealth (Benicia, CA), will present preliminary results of the first osteoarthritis human clinical trial conducted on UC-II undenatured type II collagen for those with osteoarthritis. The trial has been designed to measure the efficacy of UC-II compared to standard glucosamine and chondroitin treatments. Every attendee will be entered to win two tickets to Cirque du Soleil's KA at the MGM Grand in Las Vegas. Just as Cirque du Soleil reinvented the circus 23 years ago, InterHealth has been inventing nutritional categories for 20 years through its steadfast commitment to solid, clinical research. For more information, contact Interhealth Nutraceuticals (Benicia, CA) by visiting www.interhealthusa.com or calling 800/783-4636.
Cosmeceuticals and Dietary Supplements
Tuesday, Nov. 6, 4:00 P.M. to 4:50 P.M., Lido Room 3001-3002
Lakshmi Prakash, PhD, vice president of innovation and business development at Sabinsa Corp. (Piscataway, NJ), will cover the latest trends in cosmeceuticals, including innovative and novel ingredients and how those ingredients can be used in a variety of applications. The session is aimed at the direct link between health, wellness, and beauty. Natural personal care is one of the fastest-growing segments in the natural-products industry and consumers are embracing skin, hair, and body-care products infused with functional ingredients, according to Todd Norton, president of Sabinsa. For more information, contact Sabinsa by visiting www.sabinsa.com or calling 732/777-1111.
HMRlignan and Women's Health
Tuesday, Nov. 6, 3:00 P.M., Lido Room 3101-3102, Level 3
Dr. Donald Brown, an authority on evidence-based natural medicines, will present new research from the clinical trial conducted by Medicus Research that explores the effect of HMRlignan™ on enterolactone production and estrogen metabolite levels in post-menopausal women. Dr. Brown and Jay Udani, M.D., one of the researchers who conducted the study, will participate in a Q&A session. Dr. Brown and Dr. Udani will be available for interviews immediately following the presentation. One-on-one interviews with Dr. Brown will be arranged in booth 22077. For more information, contact Linnea by visiting www.linnea-worldwide.com or calling 888/253-0044.