Curcumin with piperine supports liver function, says recent study

November 22, 2019

A study recently published in the Journal of Cellular Biochemistry1 found that supplementation with Sabinsa’s patented curcumin extract Curcumin C3 Complex combined with the patented piperine BioPerine, supported liver function in subjects with Non-Alcoholic Fatty Liver Disease (NAFLD). A chronic liver condition that effects about 25% of the U.S. population, according to the American Liver Foundation, NAFLD has no approved pharmaceutical treatments, and is commonly associated with metabolic syndrome and cardiovascular diseases.   

In the study, 70 subjects with ultrasound-determined NAFLD were randomized to either receive 500 mg of curcumin extract with 5 mg of piperine daily, or placebo for 12 weeks. Results showed that supplementation significantly reduced elevated liver function parameters including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, as well as cholesterol, low-density lipoprotein cholesterol, iron, hemoglobin, and increased total iron-binding capacity. Based on sonography, the supplement group also saw improved NAFLD severity, compared to placebo.

“We're encouraged by the researchers’ conclusion that combined supplementation of C3 Complex and BioPerine may provide a safe and viable method for curtailing the progress of NAFLD,” said Sabinsa founder Muhammed Majeed, PhD, in a press release.


1. Panahi Y et al. “Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial.” Journal of Cellular Biochemistry, vol. 120, no. 9 (2019): 15989-15996